186

Sarac, Erdal; Krishnan, Radha; Gayetsky, M.; Madenci, L.; Gemmel, David

doi:10.1053/j.ajkd.2007.02.193

Cited by 1 publication

(1 citation statement)

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“…Generally, the GI absorption mechanism is much slower and less efficient than iron absorbed followed by IV injection of the IONPs, which is an important factor to consider when the IONPs are administrated for increasing the iron supply in the body for patients with anemia. 305,306 However, delivery of iron orally is safer since overdosing via this route is difficult.…”

Section: Metabolic Pathway Of the Ionpsmentioning

confidence: 99%

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

et al. 2015

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Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades, either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs, nucleic acids and peptides for controlled delivery to specific organs and tissues. Most of these novel applications require elaborate tuning of the physiochemical and surface properties of the IONPs. As new IONPs designs are envisioned, synergistic consideration of the body's innate biological barriers against the administered nanoparticles and the short and long-term side effects of the IONPs become even more essential. There are several important criteria (e.g. size and size-distribution, charge, coating molecules, and plasma protein adsorption) that can be effectively tuned to control the in vivo pharmacokinetics and biodistribution of the IONPs. This paper reviews these crucial parameters, in light of biological barriers in the body, and the latest IONPs design strategies used to overcome them. A careful review of the long-term biodistribution and side effects of the IONPs in relation to nanoparticle design is also given. While the discussions presented in this review are specific to IONPs, some of the information can be readily applied to other nanoparticle systems, such as gold, silver, silica, calcium phosphates and various polymers.

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Section: Metabolic Pathway Of the Ionpsmentioning

confidence: 99%