18F-FACBC (anti1-amino-3-18F-fluorocyclobutane-1-carboxylic acid) versus 11C-choline PET/CT in prostate cancer relapse: results of a prospective trial

Abstract

(18)F-FACBC can be considered an alternative tracer superior to (11)C-choline in the setting of patients with biochemical relapse after radical prostatectomy.

A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer

“…Median (range) PSA was 14.6 (3.7-56.9) ng/mL, median (range) biopsy Gleason score was 8 (7)(8)(9), and the clinical stage ranged from cT2b to cT3b.…”

“…Furthermore, MRI lacks the sensitivity for accurate staging of the regional lymph nodes (N-staging) [6]. PET/CT imaging with the synthetic amino acid analog radiotracer anti-1-amino-3-[ , on the other hand, shows promise for N-staging in both primary [7] and recurrent PCa [7][8][9] and may be complementary to mpMRI for detection and characterisation of prostate tumours [10,11].…”

Evaluation of Prostate Cancer with Radiolabeled Amino Acid Analogs

“…Findings from this early report were confirmed through an interim analysis (58). A final report from this trial for 89 patients for whom the reference standard of clinical follow-up for at least 1 y was available provided a complete description of diagnostic performance (59). In this analysis, choline and 18 F-fluciclovine had sensitivities of 32% and 37%, specificities of 40% and 67%, accuracies of 32% and 38%, PPVs of 90% and 97%, and negative predictive values of 3% and 4%, respectively; these results confirmed the overall superior performance of 18 F-fluciclovine.…”

“…In a recently completed study at the University of Bologna, 100 patients with biochemical failure after radical treatment underwent 11 C-choline PET and 18 Ffluciclovine PET within 1 wk. The results of preliminary, interim, and final analyses from this trial have been published (57)(58)(59).…”

Combined 18F-Fluciclovine PET/MRI Shows Potential for Detection and Characterization of High-Risk Prostate Cancer

“…PET imaging with the synthetic amino acid analog radiotracer anti-1-amino-3- with biochemical relapse following initial treatment with curative intent (9)(10)(11). For primary prostate cancer, the metabolic information derived from 18 F-Fluciclovine PET images could be useful for detection and characterization of localized tumors (12)(13)(14) and may be complementary to multiparametric MRI (12).…”