18F-FAPI-42 PET/CT Findings in a Patient With Left Ventricular Mural Thrombus

Abstract

18F-FAPI-42 PET/CT is a novel imaging tool targeting fibroblast activation protein (FAP). We describe the 18F-FAPI-42 PET/CT findings of a left ventricular mural thrombus in a 50-year-old man who had chest tightness. The 18F-FAPI-42 PET/CT showed annular uptake at the apex of the left ventricle, but there was no uptake of 18F-FDG. This case showed that abnormal 18F-FAPI-42 uptake in the heart may be associated with mural thrombus and should be evaluated clinically.

99mTc-PYP and 68Ga-FAPI PET/CT Images of Hereditary Transthyretin Amyloidosis With Cardiac Involvement

“…FAPI uptake was shown in cardiac diseases including mural thrombus, myocarditis, and cardiomyopathy. [5][6][7][8] FAPI PET can be useful as a diagnostic marker in cardiac sarcoidosis in FDG PET-negative patients, and in light chain amyloidosis with cardiac involvement, increased FAPI uptake was shown recently. [9][10][11] To our knowledge, this is the first case of a patient with hereditary transthyretin amyloidosis with cardiac involvement, which FAPI PET showed diffuse increased myocardial uptake.…”

“…FAPI is a more recent radiotracer, which can show fibroblast activation. FAPI uptake was shown in cardiac diseases including mural thrombus, myocarditis, and cardiomyopathy 5–8 . FAPI PET can be useful as a diagnostic marker in cardiac sarcoidosis in FDG PET-negative patients, and in light chain amyloidosis with cardiac involvement, increased FAPI uptake was shown recently 9–11 .…”