18F-FDG PET/CT Findings in Cytomegalovirus Colitis

Kjaer, Anna Sophie L; Ribberholt, Iben; Thomsen, Kim; Ibsen, Per; Markova, Elena; Graff, Jesper

doi:10.3390/diagnostics9010003

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…CMV infections can show increased FDG uptake in PET scans. For example, lymphadenitis [ 20 ], GI infections [ 27 , 28 ], and infectious mononucleosis [ 29 ]. A case of CMV lymphadenitis mimicking lymphoma relapse in PET scan has been reported [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

Huang

et al. 2021

Infect Dis Ther

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Introduction: Histopathological characteristics of cytomegalovirus (CMV) lymphadenitis have been well described. Rare studies have reported the immune status and clinical features. Clinically, experts believed that CMV lymphadenitis develops in immunocompromised and immunocompetent patients. Infectious mononucleosis (IM)-like syndrome is the most well-known clinical presentation. Methods: We reviewed archived CMV immunohistochemical stains on lymphoid tissues. The clinicopathological features of CMVpositive cases were studied. Results: For lymph nodes, we detected CMV in 29% (5/17) allogeneic peripheral blood hematopoietic stem cell transplantation

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Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

Huang

et al. 2021

Infect Dis Ther

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“…However, immunosuppression is associated with the Herpes simplex colitis or UC (Temtem et al 2021 ). CMV-associated colitis or UC has been linked to active illness, immunosuppressive medicine, steroid therapy, steroid-refractory disease progression and higher colectomy rates in IBD patients (with high-grade CMV infection) (Kjaer et al 2018 ; Mourad et al 2020 ; Hazır-Konya et al 2021 ; Leal et al 2022 ; Ouali and Achkar 2022 ). CMV has been also associated with early relapse of colitis.…”

Section: Methodsmentioning

confidence: 99%

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Zarenezhad

Abdulabbas

Kareem³

et al. 2023

Arch Microbiol

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Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal tract (GIT). IBD patients are susceptible to various infections such as viral infections due to the long-term consumption of immunosuppressive drugs and biologics. The antiviral and IBD protective traits of flavonoids have not been entirely investigated. This study objective included an overview of the protective role of flavonoids quercetin and silymarin in viral-associated IBD. Several viral agents such as cytomegalovirus (CMV), Epstein–Barr virus (EBV), varicella zoster virus (VZV) and enteric viruses can be reactivated and thus develop or exacerbate the IBD conditions or eventually facilitate the disease remission. Flavonoids such as quercetin and silymarin are non-toxic and safe bioactive compounds with remarkable anti-oxidant, anti-inflammatory and anti-viral effects. Mechanisms of anti-inflammatory and antiviral effects of silymarin and quercetin mainly include immune modulation and inhibition of caspase enzymes, viral binding and replication, RNA synthesis, viral proteases and viral assembly. In the nutraceutical sector, natural flavonoids low bioavailability and solubility necessitate the application of delivery systems to enhance their efficacy. This review study provided an updated understanding of the protective role of quercetin and silymarin against viral-associated IBD.

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Association Between Inflammatory Bowel Disease and Viral Infections

et al. 2023

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Chronic inflammatory gastrointestinal diseases such as Crohn's disease (CD) and ulcerative colitis (UC) are known as inflammatory bowel disorders (IBD). Patients with inflammatory bowel illnesses are more susceptible to viral infections. In people with IBD, viral infections have emerged as a significant issue. Viral infections are often difficult to identify and have a high morbidity and fatality rate. We reviewed studies on viral infections and IBD, concentrating on Cytomegalovirus (CMV), SARS-CoV-2, Epstein-Barr virus (EBV), enteric viruses, and hepatitis B virus (HBV). Also, the effect of IBD on these viral infections is discussed. These data suggest that patients with IBD are more likely to get viral infections. As a result, practitioners should be aware of the increased risk of viral infections in inflammatory bowel disease patients.

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18F-FDG PET/CT Findings in Cytomegalovirus Colitis

Cited by 5 publications

References 8 publications

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: an updated review

Association Between Inflammatory Bowel Disease and Viral Infections

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