18F-FDG-PET/CT in SARS-CoV-2 infection and its sequelae

Rodríguez-Alfonso, B.; Solís, S. Ruíz; Silva-Hernández, L.; Pascual, Isaac; Ibáñez, Silvia Aguado; Antón, Clara Salas

doi:10.1016/j.remnie.2021.07.005

Cited by 14 publications

(17 citation statements)

References 75 publications

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“…Indeed, many survivors of COVID-19 have chronic post-viral complications similar to the previous severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome pandemics [6]. A generally accepted standardized clinical case definition of this post-viral state is lacking [7]. Various terminologies and definitions, including long COVID, COVID long-haulers, post-acute COVID-19, late sequelae of COVID-19, or post-COVID-19 have been proposed and controversies still exist about the correct naming.…”

Section: Introductionmentioning

confidence: 99%

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18F-FDG-PET Imaging for Post-COVID-19 Brain and Skeletal Muscle Alterations

Rudroff

Workman

Ponto

2021

Viruses

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Scientific evidence concerning the subacute and long-term effects of coronavirus disease 2019 (COVID-19) is on the rise. It has been established that infection by serious acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a systemic process that involves multiple organs. The complications and long-term consequences of COVID-19 are diverse and patients need a multidisciplinary treatment approach in the acute and post-acute stages of the disease. A significant proportion of COVID-19 patients experience neurological manifestations, some enduring for several months post-recovery. However, brain and skeletal muscle changes resultant from SARS CoV-2 infection remain largely unknown. Here, we provide a brief overview of the current knowledge, and usefulness, of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) to investigate brain and skeletal muscles changes in Post-COVID-19 patients with persistent symptoms. Furthermore, a brief discussion of future 18F-FDG-PET/CT applications that might advance the current knowledge of the pathogenesis of post-COVID-19 is also provided.

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Section: Introductionmentioning

confidence: 99%

“…18 F-FDG-PET/CT can be a useful tool to detect or rule out severe concomitant processes. Alterations of brain metabolism shown with this technique may be a marker of the systemic process [7]. However, a review of literature focused on amalgamating the results of PET scans in post-COVID-19 patients has not been undertaken.…”

Section: Introductionmentioning

confidence: 99%

18F-FDG-PET Imaging for Post-COVID-19 Brain and Skeletal Muscle Alterations

Rudroff

Workman

Ponto

2021

Viruses

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“…SARS-CoV-2 virus mainly caused viral pneumonia with intense F-18 FDG uptake during the infectious process. However, persistent F-18 FDG uptake in the lung parenchyma could be observed even the improvement of clinical symptoms and CT finding, while F-18 FDG uptake remained unknown on the exact time period for resolution [ 26 , 27 ]. Persistent intense F-18 FDG uptake in lung parenchyma even at the recovery stage might potentially indicate a high level of inflammatory process for prediction of further damages to lung parenchyma [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19

Kiatkittikul

Promteangtrong

Kunawudhi

et al. 2022

Nucl Med Mol Imaging

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Purpose The study aimed to investigate imaging abnormalities associated with post-acute COVID-19 using F-18 FDG PET/CT and PET/ rsfMRI brain. Methods We retrospectively recruited 13 patients with post-acute COVID-19. The post-acute COVID-19 symptoms and neuropsychiatric tests were performed before F-18 FDG PET/CT whole body with PET/rsfMRI brain. Qualitative and semiquantitative analyses were also conducted in both whole body and brain images. Results Among the 13 patients, 8 (61.5%) had myositis, followed by 8 (61.5%) with vasculitis (mainly in the thoracic aorta), and 7 (53.8%) with lung abnormalities.. Interestingly, one patient with a very high serum RBD IgG antibody demonstrated diffuse myositis throughout the body which potentially associated with immune-mediated myositis. One patient experienced psoriasis exacerbation with autoimmune-mediated after COVID-19. Most patients had multiple areas of abnormal brain connectivity involving the frontal and parieto-temporo-occipital lobes, as well as the thalamus. Conclusion The whole body F-18 FDG PET can be a potential tool to assess inflammatory process and support the hyperinflammatory etiology, mainly for lesions in skeletal muscle, vascular wall, and lung, as well as, multiple brain abnormalities in post-acute COVID-19. Nonetheless, further studies are recommended to confirm the results.

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“…The urgency of imaging patients acutely ill with COVID-19 as well as following up post-COVID patients and those receiving vaccines, did not allow for time to create SARS-CoV-2 specific imaging agents. The domineering modality so far has been FDG-PET/CT covered in several excellent reviews (55,56) while SPECT imaging also contributes, for example, toward imaging of pulmonary emboli in COVID patients (57). As COVID-19 will gradually become endemic, it is only a matter of time when COVID-specific PET and SPECT imaging agents are developed.…”

Section: Imaging Of Viral Infectionsmentioning

confidence: 99%

Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives

Dadachova

Rangel

2022

Front. Med.

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COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging modalities has always played an important role in diagnosis of infections and distinguishing them from the sterile inflammation. In addition to the clinically available radiopharmaceuticals there has been a decades-long effort to develop more specific imaging agents with some examples being radiolabeled antibiotics and antimicrobial peptides for bacterial imaging, radiolabeled anti-fungals for fungal infections imaging, radiolabeled pathogen-specific antibodies and molecular engineered constructs. In this opinion piece, we would like to discuss some examples of the work published in the last decade on developing nuclear imaging agents for bacterial, fungal, and viral infections in order to generate more interest among nuclear medicine community toward conducting clinical trials of these novel probes, as well as toward developing novel radiotracers for imaging infections.

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18F-FDG-PET/CT in SARS-CoV-2 infection and its sequelae

Cited by 14 publications

References 75 publications

18F-FDG-PET Imaging for Post-COVID-19 Brain and Skeletal Muscle Alterations

18F-FDG-PET Imaging for Post-COVID-19 Brain and Skeletal Muscle Alterations

Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19

Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives

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