[18F]FDG PET/MRI in rectal cancer

Crimì, Filippo; Valeggia, Silvia; Baffoni, Luca; Stramare, Roberto; Lacognata, Carmelo; Spolverato, Gaya; Albertoni, Laura; Spimpolo, Alessandro; Evangelista, Laura; Zucchetta, Pietro; Cecchin, Diego; Pucciarelli, Salvatore

doi:10.1007/s12149-021-01580-0

Cited by 29 publications

(25 citation statements)

References 30 publications

(96 reference statements)

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“…The systematic review of Crimì et al in 2021 revealed that the reported sensitivity of T staging in [18F] FDG PET/MRI was in the range of 94-100%, specificity 73-94%, and accuracy 92-100%. The reported sensitivity, specificity, and accuracy for N staging were 90-93%, 92-94%, and 42-92% accordingly [53].…”

Section: Positron Emission Tomography/magnetic Resonance Imaging (Pet/mri)mentioning

confidence: 99%

Evaluation and Predictive Factors of Complete Response in Rectal Cancer after Neoadjuvant Chemoradiation Therapy

Kokaine

Gardovskis

2021

Medicina

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The response to neoadjuvant chemoradiation therapy is an important prognostic factor for locally advanced rectal cancer. Although the majority of the patients after neoadjuvant therapy are referred to following surgery, the clinical data show that complete clinical or pathological response is found in a significant proportion of the patients. Diagnostic accuracy of confirming the complete response has a crucial role in further management of a rectal cancer patient. As the rate of clinical complete response, unfortunately, is not always consistent with pathological complete response, accurate diagnostic parameters and predictive markers of tumor response may help to guide more personalized treatment strategies and identify potential candidates for nonoperative management more safely. The management of complete response demands interdisciplinary collaboration including oncologists, radiotherapists, radiologists, pathologists, endoscopists and surgeons, because the absence of a multidisciplinary approach may compromise the oncological outcome. Prediction and improvement of rectal cancer response to neoadjuvant therapy is still an active and challenging field of further research. This literature review is summarizing the main, currently known clinical information about the complete response that could be useful in case if encountering such condition in rectal cancer patients after neoadjuvant chemoradiation therapy, using as a source PubMed publications from 2010–2021 matching the search terms “rectal cancer”, “neoadjuvant therapy” and “response”.

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Section: Positron Emission Tomography/magnetic Resonance Imaging (Pet/mri)mentioning

confidence: 99%

Evaluation and Predictive Factors of Complete Response in Rectal Cancer after Neoadjuvant Chemoradiation Therapy

Kokaine

Gardovskis

2021

Medicina

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“…As some exam-ples, the conjugation of 99mTc with silica [202], iron oxide [203] or gold [204] NPs was exploited for SPECT/MRI or SPECT/CT imaging of tumors in preclinical mouse models. Likewise, the conjugation of 18F with iron oxide NP was found effective for dual imaging with PET/MRI of stem cell biodistribution [205] as well as for monitoring anti-angiogenic therapeutic effects in breast cancer xenograft mouse models [206] and diagnosis of rectal cancer in clinics [207]. Importantly, since PET/MRI systems have become operational worldwide, several imaging protocols involving the use of 18F for whole body scanning in oncology are currently under standardization for patient management in clinics [208].…”

Section: In Vitro and In Vivo Tracking Of Np Deliverymentioning

confidence: 99%

Nanotechnology-Assisted Cell Tracking

et al. 2022

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The usefulness of nanoparticles (NPs) in the diagnostic and/or therapeutic sector is derived from their aptitude for navigating intra- and extracellular barriers successfully and to be spatiotemporally targeted. In this context, the optimization of NP delivery platforms is technologically related to the exploitation of the mechanisms involved in the NP–cell interaction. This review provides a detailed overview of the available technologies focusing on cell–NP interaction/detection by describing their applications in the fields of cancer and regenerative medicine. Specifically, a literature survey has been performed to analyze the key nanocarrier-impacting elements, such as NP typology and functionalization, the ability to tune cell interaction mechanisms under in vitro and in vivo conditions by framing, and at the same time, the imaging devices supporting NP delivery assessment, and consideration of their specificity and sensitivity. Although the large amount of literature information on the designs and applications of cell membrane-coated NPs has reached the extent at which it could be considered a mature branch of nanomedicine ready to be translated to the clinic, the technology applied to the biomimetic functionalization strategy of the design of NPs for directing cell labelling and intracellular retention appears less advanced. These approaches, if properly scaled up, will present diverse biomedical applications and make a positive impact on human health.

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“…The combination of morphological, functional and metabolic information in the same test has raised this new technique as a possible "one-stop-shop" tool in oncological imaging that can aid in the diagnosis and clinical management of oncologic patients with a lower biological cost. In the clinical setting, PET/MRI was primarily used for prostate cancer, neuro-oncological diseases, soft-tissue sarcomas, colorectal cancer, pediatric malignancies and in cases of persistent clinical suspicion of abdominal malignancy with negative imaging findings [15,16].…”

mentioning

confidence: 99%