18F-Fluorodeoxyglucose-positron emission tomography: A new explorative perspective

Schirmer, Michael; Calamia, Kenneth; Wenger, Martin; Klauser, Andrea; Salvarani, Carlo; Moncayo, Roy

doi:10.1016/s0531-5565(02)00267-x

Cited by 25 publications

(8 citation statements)

References 45 publications

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“…Fluorine-18 labelled deoxyglucose (electron capture, half-life 110 min) is one of the most widely used tracers for PET imaging to detect changes in glucose metabolism in pathophysiological processes [429]. 18 F-fluorodeoxyglucose-positron emission tomography ( 18 F-FDG-PET) is also used for screening, localization and follow-up of hypermetabolic processes including malignancies, infections and autoimmune processes [430].…”

Section: Group 17: the Halogensmentioning

confidence: 99%

The elements of life and medicines

Chellan

Sadler

2015

Phil. Trans. R. Soc. A.

197

117

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Which elements are essential for human life? Here we make an element-by-element journey through the periodic table and attempt to assess whether elements are essential or not, and if they are, whether there is a relevant code for them in the human genome. There are many difficulties such as the human biochemistry of several so-called essential elements is not well understood, and it is not clear how we should classify elements that are involved in the destruction of invading microorganisms, or elements which are essential for microorganisms with which we live in symbiosis. In general, genes do not code for the elements themselves, but for specific chemical species, i.e. for the element, its oxidation state, type and number of coordinated ligands, and the coordination geometry. Today, the biological periodic table is in a position somewhat similar to Mendeleev's chemical periodic table of 1869: there are gaps and we need to do more research to fill them. The periodic table also offers potential for novel therapeutic and diagnostic agents, based on not only essential elements, but also non-essential elements, and on radionuclides. Although the potential for inorganic chemistry in medicine was realized more than 2000 years ago, this area of research is still in its infancy. Future advances in the design of inorganic drugs require more knowledge of their mechanism of action, including target sites and metabolism. Temporal speciation of elements in their biological environments at the atomic level is a major challenge, for which new methods are urgently needed.

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Section: Group 17: the Halogensmentioning

confidence: 99%

The elements of life and medicines

Chellan

Sadler

2015

Phil. Trans. R. Soc. A.

197

117

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“…It is possible that imaging with 18 F-fluorodeoxyglucose ( 18 F-FDG) may directly reflect the state of local cellular energy metabolism. PET/CT scans have been widely applied in adults and children but are very rarely used in newborns (9). …”

Section: Introductionmentioning

confidence: 99%

Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using 18F-fluorodeoxyglucose positron emission computed tomography

Luo

Dong

et al. 2014

Experimental and Therapeutic Medicine

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It remains unclear whether mild hypothermia affects energy metabolism in the brain tissue of newborns with hypoxic-ischaemic encephalopathy (HIE). The current study aimed to investigate the effect of mild hypothermia on energy metabolism in neonatal HIE and assess brain energy metabolism using position emission tomography/computed tomography (PET/CT) scanning. The mean standardised uptake values of 18F-fluorodeoxyglucose (18F-FDG) were used to determine the glucose metabolic rate in various brain anatomical regions, including the thalamus, basal ganglia and the frontal, parietal and occipital lobes. The rate of glucose metabolism significantly improved following treatment with mild hypothermia therapy and conventional therapy (P<0.001). Prior to the treatment, no significant differences were identified between the groups (P>0.05). Following treatment, the rate of glucose metabolism was significantly improved in the mild hypothermia therapy group compared with that in the conventional therapy group (P<0.001). Thus, these results indicate that mild hypothermia therapy effectively promotes the recovery of patients with neonatal HIE. 18F-FDG PET/CT scanning may be used to provide reference values for the assessment of energetic metabolism in patients with neonatal HIE.

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“…It is an established functional imaging modality in oncology and neurology (5), but has recently been introduced in the evaluation of various inflammatory diseases, particularly large-vessel vasculitis (6).…”

Section: Introductionmentioning

confidence: 99%

¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

Vaglio¹,

Versari²,

Fraternali³

et al. 2005

Arthritis & Rheumatism

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18F-Fluorodeoxyglucose-positron emission tomography: A new explorative perspective

Cited by 25 publications

References 45 publications

The elements of life and medicines

The elements of life and medicines

Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using 18F-fluorodeoxyglucose positron emission computed tomography

¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

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18F-Fluorodeoxyglucose-positron emission tomography: A new explorative perspective

Cited by 25 publications

References 45 publications

The elements of life and medicines

The elements of life and medicines

Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using 18F-fluorodeoxyglucose positron emission computed tomography

18F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis

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¹⁸F‐fluorodeoxyglucose positron emission tomography in the diagnosis and followup of idiopathic retroperitoneal fibrosis