[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Guillot, Martin; Chartrand, Gabriel; Chav, R.; Rousseau, Jacques; Martel‐Pelletier, Johanne; Pelletier, Jean‐Pierre; Guise, Jacques A. de; Troncy, Éric

doi:10.1016/j.tvjl.2015.03.023

Cited by 22 publications

(21 citation statements)

References 36 publications

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“…These findings reflect sustained cerebral nociceptive inputs and increased activity of descending modulatory pathways (Guillot et al. ). Temporal summation is considered to be an important tool in the study of maladaptive pain.…”

Section: Discussionmentioning

confidence: 97%

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Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

Monteiro

Klinck

Moreau

et al. 2016

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 97%

“…In the research setting, outcome assessment measures to characterize functional disability and maladaptive pain secondary to central sensitization have been validated (Guillot et al. , , , ).…”

Section: Introductionmentioning

confidence: 99%

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

Monteiro

Klinck

Moreau

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…Central sensitisation is expressed as pain hypersensitivity characterised by decreased tactile (von Frey) threshold [3,4], decreased RMTS [4], sustained cerebral nociceptive inputs (secondary somatosensory cortex) and increased activity of descending modulatory pathways (thalamus and periaqueductal gray matter) [14] in cats with OA. Temporal summation is considered to be an important tool for the study of maladaptive pain as it reflects the early phase of central sensitisation (“wind-up”).…”

Section: Discussionmentioning

confidence: 99%

“…In feline clinical practice, the signs of OA are very subtle and unspecific [10], and client-based questionnaires and activity monitoring have been used to assess pain-induced behaviours in osteoarthritic cats [6,11,12]. In the research setting, OA-related outcome assessments have been recently validated to characterise functional disability and maladaptive pain secondary to central sensitisation [3,4,13,14]. Indeed, brain functional imaging in cats with OA revealed sustained ascending nociceptive inputs and increased activity of the descending modulatory pathways, both consistent with central sensitisation [14].…”

Section: Introductionmentioning

confidence: 99%

“…In the research setting, OA-related outcome assessments have been recently validated to characterise functional disability and maladaptive pain secondary to central sensitisation [3,4,13,14]. Indeed, brain functional imaging in cats with OA revealed sustained ascending nociceptive inputs and increased activity of the descending modulatory pathways, both consistent with central sensitisation [14]. The analgesic treatment of OA in cats has been classically based on the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam [2,3,11,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis

et al. 2017

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ObjectivesThis study aimed to (1) compare outcome assessments in normal and osteoarthritic cats and (2) evaluate the analgesic efficacy of tramadol in feline osteoarthritis (OA), in a prospective, randomised, blinded, placebo-controlled, crossover design.MethodsTwenty cats were included after clinical examination, blood work and full body radiographs were performed. In Phase 1, outcome assessments aimed to differentiate normal (n = 5; i.e. exempt of any radiographic and clinical sign of OA) from OA (n = 15) cats. In Phase 2, OA cats were treated twice daily with a placebo (PG: cornstarch 15 mg) or tramadol (TG: 3 mg/kg) orally for 19 days, with a 3-month washout period between treatments. Evaluations were performed in normal and OA cats at baseline and consisted of: 1) peak vertical force (PVF) after staircase exercise; 2) telemetered night-time motor activity (NMA); and 3) response to mechanical temporal summation (RMTS). After treatment, PVF, NMA and RMTS evaluations were repeated in OA cats. Data were analysed with mixed model methods with an alpha-threshold of 5%.ResultsPhase 1: 1) PVF (% of body weight; mean ± SD) was higher in normal (59 ± 10.5) than in OA cats (50.6 ± 5.7) (p = 0.005); 2) NMA (no unit) was not different between groups; 3) RMTS (number of stimuli; median (range)) was higher in normal [29.5 (23.5–30)] than in OA cats [14 (8.5–28)] (p < 0.0001). Phase 2: PVF, NMA and RMTS presented a treatment effect (p = 0.024, p = 0.008 and p = 0.018, respectively). No clinically important adverse-effects were observed.ConclusionOutcome assessments such as kinetics (PVF) and evaluation of central sensitisation (RMTS) are discriminant of OA status. Mobility measured by NMA was not discriminant of OA status, however it increased in OA cats with tramadol treatment. Nociceptive hypersensitivity quantified by RMTS was evident in OA cats and was responsive to tramadol treatment.

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“Visualization” of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

et al. 2022

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We hypothesised that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus. Patients scheduled for surgery due to LDH underwent 18 F-uorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) less than two weeks prior to surgery. Their thalamic FDG uptake was measured and expressed as the mean and partial volume corrected mean standardized uptake values (SUVmean and cSUVmean). These measures were compared with patient-related outcome measures collected pre-and 1-year postoperatively: back and leg pain on a 0-100 VAS scale and health related quality of life as measured by the EuroQol-5D (EQ-5D). Twenty-six patients (10 females) aged 49.7 ± 7.4 (mean ± SD) years were included. There was a signi cant correlation between painful body side and increased contralateral thalamic uptake of FDG, with regard to cSUVmean values. Correlation analyses including clinical parameters and cSUVmean indicated some association with 1-year change in EQ-5D.These preliminary data sustain the hypothesis that unilateral pain in patients with LDH is associated with increased glucose metabolism in the contralateral thalamus, suggestion a central role of thalamus in chronic pain perception.

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[18F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Cited by 22 publications

References 36 publications

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis

“Visualization” of pain using cerebral 18F-FDG PET/CT following surgical treatment of lumbar disc herniation

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