18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload

Han, Jun; Su, Guanhua; Wang, Yuhui; Yongxin, Lu; Zhao, Hongfeng; Shuai, Xinxin

doi:10.1007/s11596-020-2232-y

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…18β-GA can improve ischemia‒reperfusion with anemoniasulcata toxin II-induced diastolic cardiac dysfunction in a dose-dependent manner in rats. The action mechanism of 18β-GA against diastolic cardiac dysfunction may be through inhibiting the enhanced late sodium currents ( Han et al, 2020 ). GA can also relieve the susceptibility and incidence of fatal ventricular arrhythmia during reperfusion in rat hearts by inhibiting both the L-type calcium current and transient outward potassium current as well as prolonging the duration of the action potential ( Wu et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid

Gao

Yang³

et al. 2022

Front. Pharmacol.

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Licorice, a herbal product derived from the root of Glycyrrhiza species, has been used as a sweetening agent and traditional herbal medicine for hundreds of years. Glycyrrhizic acid (GL) and glycyrrhetinic acid (GA) are the most important active ingredients in licorice. Both GL and GA have pharmacological effects against tumors, inflammation, viral infection, liver diseases, neurological diseases, and metabolic diseases. However, they also exhibit differences. KEGG analysis indicated that licorice is involved in neuroactive ligand‒receptor interactions, while 18β-GA is mostly involved in arrhythmogenic right ventricular cardiomyopathy. In this article, we comprehensively review the therapeutic potential of GL and GA by focusing on their pharmacological effects and working mechanisms. We systemically examine the structure-activity relationship of GL, GA and their isomers. Based on the various pharmacological activities of GL, GA and their isomers, we propose further development of structural derivatives of GA after chemical structure modification, with less cytotoxicity but higher targeting specificity. More research is needed on the clinical applications of licorice and its active ingredients.

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Section: Resultsmentioning

confidence: 99%

Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid

Gao

Yang³

et al. 2022

Front. Pharmacol.

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“…Similar inhibitory effects of the PI3K/Akt pathway were described by another study to be the cardioprotective mechanism of GA; Chu et al [ 181 ] reported that GA alleviates oxidative stress, inflammation, and apoptosis in a mice model of myocardial infarction via PI3K/Akt pathway inhibition while also decreasing Ca 2+ influx through L-type calcium channels, thus reducing cell contractility. The GA effect on Ca 2+ was also described in an ischemia-reperfusion rat model that demonstrated the significant decrease of intracellular Ca 2+ levels in cardiomyocytes through the inhibition of the late sodium current, thus improving diastolic function in patients with heart failure [ 182 ].…”

Section: Glycyrrhetinic Acidmentioning

confidence: 99%

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Mioc

Prodea

Racoviceanu

et al. 2022

IJMS

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Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic, antiviral, and antiparasitic effects. They are a subclass of triterpenes bearing a characteristic lipophilic structure that imprints unfavorable in vivo properties which subsequently limit their applications. The early investigation of the mechanism of action (MOA) of a drug candidate can provide valuable information regarding the possible side effects and drug interactions that may occur after administration. The current paper aimed to summarize the most recent (last 5 years) studies regarding the MOA of betulinic acid, boswellic acid, glycyrrhetinic acid, madecassic acid, moronic acid, and pomolic acid in order to provide scientists with updated and accessible material on the topic that could contribute to the development of future studies; the paper stands as the sequel of our previously published paper regarding the MOA of triterpenic acids with therapeutic value. The recent literature published on the topic has highlighted the role of triterpenic acids in several signaling pathways including PI3/AKT/mTOR, TNF-alpha/NF-kappa B, JNK-p38, HIF-α/AMPK, and Grb2/Sos/Ras/MAPK, which trigger their various biological activities.

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“…In addition, some reports demonstrated that naringin [29,30], hesperidin [31,32], hesperetin [34,35], rutin [36], and tangeretin [40] had vasodilatory activity and cardioprotective activity. Note that, 6-gingerol could also protect the heart by suppressing myocardial ischemia-induced inflammation through the PI3K/Akt-Dependent Mechanism [42], and glycyrrhetinic acid could improve cardiac diastolic function to some extent through attenuating intracellular calcium overload [43].…”

Section: Bioavailable Compounds-chd Targets Network Analysismentioning

confidence: 99%

Metabolic profile and potential mechanisms of Wendan decoction on coronary heart disease by ultra‐high‐performance quadrupole time of flight‐mass spectrometry combined with network pharmacology analysis

Wang

Chen

Zhang

et al. 2022

J of Separation Science

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Wendan decoction, a well‐known classical traditional Chinese medicine prescription, has been widely used in the clinical application of coronary heart disease for thousands of years. However, due to a lack of research on the overall metabolism of Wendan decoction, the bioavailable components responsible for the therapeutic effects remain unclear, hindering the revelation of its mechanisms against coronary heart disease. Consequently, an efficient joint research pattern combined with characterization of the metabolic profile and network pharmacology analysis was proposed. As a result, a total of 172 Wendan decoction‐related xenobiotics (57 prototypes and 115 metabolites) were detected based on the exploration of the typical metabolic pathways of representative pure compounds in vivo, describing their multi‐component metabolic characteristics comprehensively. Subsequently, an integrated network of “herbs‐bioavailable compounds‐coronary heart disease targets‐pathways‐therapeutic effects” was constructed, and its seven compounds were finally screened out as the key components acting on five main targets of coronary heart disease. Overall, this work not only provided a crucial biological foundation for interpreting the effective components and action mechanisms of Wendan decoction on coronary heart disease but also showed a reference value for revealing the bioactive components of traditional Chinese medicine prescriptions.

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18β-Glycyrrhetinic Acid Improves Cardiac Diastolic Function by Attenuating Intracellular Calcium Overload

Cited by 9 publications

References 29 publications

Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid

Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid

Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

Metabolic profile and potential mechanisms of Wendan decoction on coronary heart disease by ultra‐high‐performance quadrupole time of flight‐mass spectrometry combined with network pharmacology analysis

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