18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model

Kim, Seung-Hyung; Hong, Jung-Hee; Lee, Jieun; Lee, Young‐Cheol

doi:10.1016/j.etap.2017.03.011

Cited by 45 publications

(28 citation statements)

References 64 publications

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“…Aglycons were produced because of the sequential loss of Glc and Fuc, then, the aglycon lost CH 3 OH (32 Da) and, typically, a molecule of water. In the positive-ion mode, 3 OH] + indicated the loss of CH 3 OH (CNL of type 1), based on the fragment peaks and the literature, it was speculated to be saikosaponin D [20][21][22]. The possible fragment pathway is shown in Figure 3.…”

Section: Saikosaponinsmentioning

confidence: 99%

“…Saikosaponins are the most effective ingredients of BR. Licorice is a common TCM that is derived from the root and rhizome of Glycyrrhiza uralensis Fisch . Triterpene saponins are common and the main effective components in BR and liquorice, and triterpene saponins have received increasing attention in recent years because of their variety and extensive biological activity.…”

Section: Introductionmentioning

confidence: 99%

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A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Shan

Yang

Zhao

et al. 2018

J of Separation Science

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Bupleuri radix and liquorice are commonly used as a hepatoprotectants. Their main effective ingredients are triterpenoid saponins. It is known that the saponins in liquorice and Bupleuri radix not only promote the metabolism of sugar and lipids but also have anti-inflammatory functions and hepatoprotective effect. However, the complexity of these compounds results in difficulty in studying their pharmacodynamics and mechanism. In this study, glycosides were the main components that were identified and selected as the main research object. First, the mass spectrometry information of the main chemical components in liquorice and Bupleuri radix were collected from the literature. The characteristic fragments and neutral losses were summarized according to typical cleavage methods. Second, the samples were analysed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, and characteristic fragment filters and neutral loss filters were successfully applied to screen 18 saponins from Bupleuri radix and 23 saponins and nine flavonoid glycosides from liquorice. Rapid classification and identification of the main components in Bupleuri radix and liquorice were finally achieved. This method promoted the development of chemical components in Bupleuri radix and liquorice, and provided a new way for screening, classifying, and identifying target components in complex samples of metabolomics and pharmacokinetics.

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Section: Saikosaponinsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Shan

Yang

Zhao

et al. 2018

J of Separation Science

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“…The ratio of GATA-3, OX40L, and Tbet levels was reported to be important for Th1/Th2 balance. GATA-3 and OX40L may activate the release of Th2 cytokines, whereas Tbet commonly activates the release of Th1 cytokines [18][19][20]. The relative increase in GATA-3 levels may also moderate Th1/Th2 balance [19,20].…”

Section: Discussionmentioning

confidence: 99%

Effects of <i>tMa-Xin-Di-Tan</i> decoction on ovalbumin-induced allergic asthma in mice

Liu¹,

Xu²,

Ming³

et al. 2018

Trop. J. Pharm Res

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Purpose: To investigate the effect of the Ma-Xin-Di-Tan (MXDT) decoction on ovalbumin-induced allergic asthma (AA) in mice. Methods: Asthma was induced in mice by ovalbumin (OVA) injection, and different doses of MXDT (150, 300, and 600 mg/kg/day) were administered orally for 28 days. Pathological changes in lung tissues were examined, while levels of cytokines, including interleukin (IL)-4, IL-6, IL-17, interferon (IFN)-γ, and transforming growth factor (TGF)-β, were determined using enzyme-linked immunosorbent assays (ELISAs) of the bronchoalveolar lavage fluid. Toll-like receptor (TLR)-4, GATA-binding protein (GATA)-3, Ox40 ligand (OX40L), indoleamine 2,3-dioxygenase (IDO), forkhead box P3 (Foxp3), and T box expressed in T cells (T-bet) levels were determined in lung tissues by western blot analysis. Results: MXDT inhibited the inflammatory reaction of lung tissues in OVA-challenged mice. After treatment with MXDT, levels of IL-4, IL-6, IL-17, and TGF-β were downregulated, whereas IFN-γ levels were upregulated. In addition, MXDT decreased TLR-4, GATA-3, and OX40L levels in lung tissues but increased the expression of Foxp3, T-bet, and IDO. Conclusion: MXDT has antiallergic effects on OVA-induced AA in mice; the possible molecular mechanisms might involve the inhibition of inflammatory reactions and modulation of Th1/Th2 cytokine balance.

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“…Shin et al () studied the antiallergic effects, namely, the antiscratching behaviour and the IgE production inhibitory activity, of glycyrrhizin, 18β‐glycyrrhetinic acid, isoliquiritin, and liquiritigenin in dermatitis and asthma (Shin et al, ). In particular, 18β‐glycyrrhetinic acid attenuated the airway inflammation in an asthmatic mouse model, being classified as a novel therapeutic component for the treatment of allergic asthma (S. H. Kim, Hong, Lee, & Lee, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Pastorino

Cornara

Soares

et al. 2018

Phytotherapy Research

556

332

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In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β-glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra. Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well-being.

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18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model

Cited by 45 publications

References 64 publications

A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

A rapid classification and identification method applied to the analysis of glycosides in Bupleuri radix and liquorice by ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Effects of <i>tMa-Xin-Di-Tan</i> decoction on ovalbumin-induced allergic asthma in mice

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

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