197-LB: The Regulation of HSL by Macrophage Migration Inhibitory Factor (MIF) Contributes to Adipocyte Hypertrophy and Development of Obesity

Chen, Liujun; Huang, Yiheng; Li, Lisha; Zabihi, Haleh; Qi, Yadan; Leng, Lin; Sun, Guang; Bucala, Richard; Qi, Dake

doi:10.2337/db21-197-lb

Cited by 1 publication

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“…As a key protein in the modulation of fat mobilization [112], HSL is also regulated by other factors. In addition to being activated by cAMP/PKA phosphorylation in response to hormone stimulation, the enzyme can also be inactivated by protein phosphatase 2A (PP2A)-mediated dephosphorylation [113].…”

Section: Endoplasmic Reticulum Stress Pathwaymentioning

confidence: 99%

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis

Wang

et al. 2023

Nutrients

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According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact on the pathogenesis of alcoholic liver disease. There has been increasing recognition of the crucial role of adipose tissue in regulating systemic metabolism, far beyond that of an inert energy storage organ in recent years. The endocrine function of adipose tissue is widely recognized, and the significance of the proteins it produces and releases is still being investigated. Alcohol consumption may affect white adipose tissue (WAT) and brown adipose tissue (BAT), which interact with surrounding tissues such as the liver and intestines. This review briefly introduces the basic concept and classification of adipose tissue and summarizes the mechanism of alcohol affecting lipolysis and lipogenesis in WAT and BAT. The adipose tissue–liver axis is crucial in maintaining lipid homeostasis within the body. Therefore, this review also demonstrates the effects of alcohol consumption on the adipose tissue–liver axis to explore the role of alcohol consumption in the crosstalk between adipose tissue and the liver.

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Section: Endoplasmic Reticulum Stress Pathwaymentioning

confidence: 99%

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis

Wang

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

197-LB: The Regulation of HSL by Macrophage Migration Inhibitory Factor (MIF) Contributes to Adipocyte Hypertrophy and Development of Obesity

Cited by 1 publication

References 0 publications

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis

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