1982‐1992: A Decade of Technology Development for Guided Tissue Regeneration

Scantlebury, Todd V.

doi:10.1902/jop.1993.64.11s.1129

Cited by 201 publications

(138 citation statements)

References 2 publications

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“…Therefore, no additional bending or cutting was required during surgery, and it satisfied the space-making and clinical manageability requirements of membrane design criteria [38].…”

Section: Discussionmentioning

confidence: 91%

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Shim

Won²,

Sung

et al. 2015

Polymers

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This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to compare results with those of a non-resorbable titanium mesh membrane. After preparation of PCL/PLGA/β-TCP membranes using extrusion-based 3D printing technology; mechanical tensile testing and in vitro cell proliferation testing were performed. Implant surgery and guided bone regeneration were performed randomly in three groups (a no membrane group, a titanium membrane group, and a PCL/PLGA/β-TCP membrane group (n = 8 per group)). Histological and histometric analyses were conducted to evaluate effects on bone regeneration and osseointegration. Using the results of mechanical testing; a PCL/PLGA/β-TCP ratio of 2:6:2 was selected. The new bone areas (%) in buccal defects around implants were highest in the PCL/PLGA/β-TCP group and significantly higher than in the control group (p < 0.05). Bone-to-implant contact ratios (%) were also significantly higher in the PCL/PLGA/β-TCP and titanium groups than in the control group (p < 0.05). When the guided bone regeneration procedure was performed using the PCL/PLGA/β-TCP membrane; new bone formation around the implant and osseointegration were not inferior to those of the non-resorbable pre-formed titanium mesh membrane.

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“…Therefore, no additional bending or cutting was required during surgery, and it satisfied the space-making and clinical manageability requirements of membrane design criteria [38].…”

Section: Discussionmentioning

confidence: 91%

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Shim

Won²,

Sung

et al. 2015

Polymers

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“…[31][32][33] It has been claimed by Scantlebury that tissue integration is one of the criteria for the biomaterials to be used in the GTR technique. 34 In an another study of collagen membranes interposed between periodontal flaps and denuded root surfaces in a mongrel dog model, tissue integration was evident 10 days after implantation, and collagen membranes prevented apical migration of the epithelium during initial stages of healing. 35 A study of the biocompatibility of resorbable and nonresorbable GTR membranes in cultures of human periodontal ligament fibroblasts (HPLFs) and human osteoblast-like cells (HOLCs) also indicated that collagen membranes are very cytocompatible and may integrate into adjacent connective tissue.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Th1/Th2 cytokine profiles of initial wound healing of rats induced by PDCM and e‐PTFE

2003

J Biomed Mater Res

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The results show that the intensities of IL-2 cytokine in PDCM groups were slightly higher than those of e-PTFE groups but without statistical significance. The level of interferon-␥ in PDCM groups was lower than that of e-PTFE groups, but also without significant differences. However, expressions of Th2 cytokines (IL-4, IL-10, and IL-13) induced by e-PTFE were generally higher than those of PDCM and control groups at all times (Mann-Whitney U test, p < 0.05). In a comparison of the mean ratio of IL-2/IL-4 with the use of the Mann-Whitney U test, data for the PDCM group were generally higher than those of the e-PTFE group, with statistical significance at all time intervals (p < 0.05). A descending order of the intensity ratio of IL-2/IL-4 was PDCM groups > control groups > e-PTFE groups. These findings indicate that the cytokine profiles of PDCM, in connection with the GTR technique, demonstrate a higher trend toward Th1-dominated responses and may protect against periodontal tissue destruction, as compared to the Th2-dominated responses of e-PTFE.

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“…1 Accordingly, GTR devices that act as passive barriers have been developed, manufactured, and marketed to support proliferation and migration of periodontal ligament cells onto the periodontally compromised tooth surface and to prevent influx from the gingival connective tissue and epithelium. 2,3 Studies have also shown that alveolar bone and cementum regeneration is critically dependent on space provision by the GTR device. [4][5][6][7][8][9] With limited space provision by the barrier membrane, alveolar bone will fill the space provided by the device.…”

Section: G Uided Tissue Regeneration (Gtr) Ismentioning

confidence: 99%

Periodontal Repair in Dogs: A Bioabsorbable Calcium Carbonate Coral Implant Enhances Space Provision for Alveolar Bone Regeneration in Conjunction with Guided Tissue Regeneration

Wikesjö

Lim

Razi³

et al. 2003

Journal of Periodontology

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Background: collapse or compression of a barrier device into a periodontal defect or onto the root surface compromises outcomes following guided tissue regeneration (GTR). Bone biomaterials have been suggested to support regeneration of alveolar bone and to improve space provision with GTR devices. The objective of this study was to evaluate space provision, alveolar bone, and cementum regeneration following use of a bioabsorbable, calcium carbonate biomaterial in conjunction with GTR. Methods: Routine, critical size, 5 to 6 mm, supraalveolar, periodontal defects were created in 5 young adult beagle dogs. Alternate jaw quadrants in consecutive animals received GTR and the coral biomaterial (cGTR) or GTR alone. The animals were euthanized 4 weeks postsurgery and tissue blocks processed for histometric analysis. Results: The coral implant particles were surrounded by newly‐formed bone or immersed in connective tissue and appeared to resorb and be replaced by bone. There was limited, if any, appreciable cementum regeneration. Space provision was enhanced in cGTR compared to GTR sites (6.1 ± 1.6 versus 2.4 ± 0.8 mm2; P <0.05). Bone regeneration (height) was significantly increased in cGTR compared to GTR sites averaging 1.9 ± 0.6 and 1.2 ± 0.6 mm, respectively (P<0.05). Bone regeneration (area) was 2‐fold greater in cGTR sites compared to the GTR control (3.3 ± 1.8 versus 1.4 ± 0.5 mm2), however the difference was not statistically significant (P >0.05). Conclusions: The coral implant significantly enhanced space provision for GTR while alveolar bone formation appeared to be enhanced by its use. Increased healing intervals are needed to fully understand the biologic value of the coral implant a s an adjunct to GTR. J Periodontol2003;74:957‐964.

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1982‐1992: A Decade of Technology Development for Guided Tissue Regeneration

Cited by 201 publications

References 2 publications

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Comparison of Th1/Th2 cytokine profiles of initial wound healing of rats induced by PDCM and e‐PTFE

Periodontal Repair in Dogs: A Bioabsorbable Calcium Carbonate Coral Implant Enhances Space Provision for Alveolar Bone Regeneration in Conjunction with Guided Tissue Regeneration

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