1990 Annual report of the American Association of Poison Control Centers National Data Collection System

Litovitz, T. A.; Bailey, Kathleen M.; Schmitz, Barbara F.; Holm, Karen C.; Klein‐Schwartz, Wendy

doi:10.1016/0735-6757(91)90216-7

Cited by 191 publications

(27 citation statements)

References 7 publications

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“…Our results also confirm the paucity of significant cases of tricyclic antidepressant poisoning (1%) and cocaine poisoning (0%) in Hong Kong which are common in the Western studies 7,8 . Our study also confirms the predominance of deliberate poisoning (57%) in comparison with accidental (5%) poisoning and habitual abuse (12%).…”

Section: Discussionsupporting

confidence: 83%

The changing pattern of self‐poisoning in Hong Kong over nine years

1996

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Three thousand four hundred and twenty poisoned patients presenting to the Accident & Emergency Department of an inner‐city hospital from July 1985 to June 1994 were studied retrospectively. There was a predominance of females (F:M = 7:3) and young adults (45% aged between 21 years and 30 years). Hypnotics and tranquilisers made up more than half of the agents taken. Most of the patients (57%) poisoned themselves deliberately. The majority of patients had taken a single drug (97%). There was a significant drop in poisoning with Mandrax (methaqualone/diphenhydramine), Lendormin (brotizolam) and aspirin (acetylsalicylic acid) after 1990 while poisoning with narcotic analgesics and hallucinogens increased significantly.

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Section: Discussionsupporting

confidence: 83%

The changing pattern of self‐poisoning in Hong Kong over nine years

1996

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“…Moreover, the times between ingestion, drawing blood samples and treatment were not specified. From the available literature ( Table 2) it seems that high peak levels of boric acid in blood over the first hours from oral ingestion are associated with poor outcome and high mortality rate [5,6,16,21]. Moreover, haemodialysis was consistently effective in shortening boric acid half life but seemed to be associated with a reduced mortality only when performed in the first 12 h from ingestion [7,18].…”

Section: Discussionmentioning

confidence: 92%

“…Since 1940, 24 reports of severe acute boric acid poisoning involving 55 children (of whom 34 died) and only 14 adults (of whom eight died) have been published [7,[10][11][12][13][14][15][16]20,21,[24][25][26]. The lethal dose in adults was between 15 and 20 g [21].…”

Section: Discussionmentioning

confidence: 98%

A case report of massive acute boric acid poisoning

Corradi

Brusasco²,

Palermo³

et al. 2010

European Journal of Emergency Medicine

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Boric acid comes as colourless, odourless white powder and, if ingested, has potential fatal effects including metabolic acidosis, acute renal failure and shock. An 82-year-old male was brought to the emergency room 3 h after unintentional ingestion of a large amount of boric acid. Clinical course was monitored by collecting data at admittance, 12 h after admission, every 24 h for 5 days and again 1 week after admission. During the first 132 h, serum and urinary concentrations of boric acid were measured. Serum boric acid levels decreased from 1800 to 530 microg/ml after haemodialysis and from 530 to 30 microg/ml during the forced diuresis period. During dialysis, boric acid clearance averaged 235 ml/min with an extraction ratio of 70%. The overall patient's condition steadily improved over 84 h after admission. In conclusion, early treatment with forced diuresis and haemodialysis may be considered for boric acid poisoning, even if signs of renal dysfunction are not apparent, to prevent severe renal damage and its complications.

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“…As the number of adults with type 2 diabetes mellitus is expected to increase (2), and the number of pediatric sulfonylurea exposures has tripled from 1990 to 2001 (3, 4), it is reasonable to assume that the number of pediatric exposures to sulfonylureas will continue to rise. This case highlights the variability in presentation, severity and duration of hypoglycemia after sulfonurea ingestion.…”

Section: Discussionmentioning

confidence: 99%

“…The Toxic Exposure Surveillance System of the American Association of Poison Control Centers reported nearly a tripling in unintended oral hypoglycemic exposures in children less than 6 years from 1990 to 2001 (3, 4). The sulfonylureas accounted for 56% of these exposures in 2001 (4), and there is a debate as to the duration of time required to monitor such exposures in the hospital.…”

Section: Introductionmentioning

confidence: 99%

Extended-Release Glipizide Overdose Presenting with Delayed Hypoglycemia and Treated with Subcutaneous Octreotide

Pelavin¹,

Abramson²,

Pon³

et al. 2009

Journal of Pediatric Endocrinology and Metabolism

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The onset of symptomatic hypoglycemia in children with ingestions of second-generation sulfonylureas has never been documented to be later than 21 hours post-ingestion. We report a case with the longest known interval, 45 hours, between ingestion of a sulfonylurea and the onset of hypoglycemia requiring medical intervention. The hypoglycemia was severe and required multiple dextrose boluses in addition to continuous dextrose infusion for 36 hours. This patient was also treated with multiple doses of subcutaneous octreotide because of persistent hypoglycemia despite the above management. This case represents the first report of subcutaneous octreotide used as a treatment for pediatric hypoglycemia secondary to sulfonylurea exposure.

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1990 Annual report of the American Association of Poison Control Centers National Data Collection System

Cited by 191 publications

References 7 publications

The changing pattern of self‐poisoning in Hong Kong over nine years

The changing pattern of self‐poisoning in Hong Kong over nine years

A case report of massive acute boric acid poisoning

Extended-Release Glipizide Overdose Presenting with Delayed Hypoglycemia and Treated with Subcutaneous Octreotide

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