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Abstract

Herpes simplex virus type 1 (HSV-1) causes a variety of infections in humans and can be found in many countries worldwide. Although the antiherpes drug, acyclovir, has been used very successfully, an acyclovir-resistant strain of HSV has recently been found in patients and drug toxicity has been reported with increasing use of it. As a potential alternative, it has been found that both a water soluble and a lipid extract of the microalga Spirulina platensis exhibit antiviral activity (HSV-1) in Vero cells. In this study, bioassay guided fractionation of a lipid extract from S. platensis led to the identification of sulphoquinovosyl diacylglycerol as the active antiviral agent. The chemical structure of this compound was confirmed by NMR and LC-mass spectroscopic analyses. Results from the study showed that the compound exhibited a remarkable activity against HSV-1 with an IC50 value of 6.8 µg/ml, which was comparable to that of acyclovir (1.5 µg/ml).

Ethanol Extraction of Polar Lipids from Nannochloropsis oceanica for Food, Feed, and Biotechnology Applications Evaluated Using Lipidomic Approaches

“…Marine phospholipids offer higher bioaccessibility and bioavailability of omega-3 lipids than triglycerides, and several phospholipids have also been reported with beneficial health effects in the prevention of several chronic diseases, such as cardiovascular diseases [8]. Marine glycolipids from the genus Nannochloropsis are also rich in omega-3 lipids and have been associated with anti-tumoral [9,10], antiviral [11,12], antibacterial [13], and anti-inflammatory [14][15][16][17] activities. They have also been described with several beneficial effects on senescence, cognitive functions, and inflammatory diseases, as well as on plasma and hepatic lipid metabolism [18,19].…”

Biogenically Synthesized Polysaccharides-Capped Silver Nanoparticles: Immunomodulatory and Antibacterial Potentialities Against Resistant Pseudomonas aeruginosa

“…Previous report of Cepoi et al indicated that, Spirulina Platensis is an ideal selection for NPs bio-fabrication because the cells have many bioactive reducing compounds (Cepoi et al, 2015). Arthrospira sp extracts have been reported to exhibit diverse activity as anticoagulant (Majdoub et al, 2009) and antiviral effects (Chirasuwan et al, 2007).…”

Effects of Nanoencapsulated Carotenoid of Spirulina platensis on the Sensory Profiles of Dark and Milk Chocolate

“…Sulfolipid compounds in spirulina have an important role in the human body in maintaining the body's resistance. Sulfoquinovosyl diacylglycerol (SQDG) compound is one of the sulfolipids extracted from Spirulina platensis, and it can be an inhibitor of herpes simplex virus type 1 (HSV-1) which can damage the human immune system [3]. High nutrition and bioactive compounds in Spirulina platensis can be a solution to the problem of malnutrition in various countries, such as vitamin A deficiency and hunger edema.…”