19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement

Kimura, Atsuomi; Narazaki, Michiko; Kanazawa, Yôko; Fujiwara, Hideaki

doi:10.1016/j.mri.2004.01.060

Cited by 26 publications

(15 citation statements)

References 24 publications

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“…Indeed, they present relatively long T 1 and short T 2 relaxation times, resulting in long image acquisition times and MR signal attenuation, respectively. In addition, the wide-range distributed chemical shifts of 19 F NMR signals tend to give rise to chemical shift artifacts in the MR image, although these chemical shifts can be used to trace the metabolism (83). However, using high fluorine concentrations, such as those accessible with PFCs, the signal-to-noise ratio will be enhanced and the scanning time decreased for high-resolution images aquisition.…”

Section: F-mrimentioning

confidence: 99%

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

2009

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Perfluorocarbons (PFCs) are fluorinated compounds that have been used for many years in clinics mainly as gas/oxygen carriers and for liquid ventilation. Besides this main application, PFCs have also been tested as contrast agents for ultrasonography and magnetic resonance imaging since the end of the 1970s. However, most of the PFCs applied as contrast agents for imaging were gaseous. This class of PFCs has been recently substituted by liquid PFCs as ultrasound contrast agents. Additionally, liquid PFCs are being tested as contrast agents for (19)F magnetic resonance imaging (MRI), to yield dual contrast agents for both ultrasonography and (19)F MRI. This review focuses on the development and applications of the different contrast agents containing liquid perfluorocarbons for ultrasonography and/or MRI: large and small size emulsions (i.e. nanoemulsions) and nanocapsules.

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Section: F-mrimentioning

confidence: 99%

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

2009

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“…[36][37][38][39][40][41] Emulsions and nano-systems encapsulating liquid perfluorocarbons (PFCs) as contrast agents for MRI have proven their potentialities for the imaging of blood pool, ventricular abnormalities, liver, thrombi, atherosclerosis, mononuclear phagocyte system, tumor, molecular imaging of angiogenesis and drug delivery carriers of anticancer drugs. However, the use of PFC emulsions is limited due to their heterogeneity, instability, split 19 F signals, as well as excessive retention within internal organs (liver, spleen, lung) for a prolonged period of time.…”

Section: Introductionmentioning

confidence: 99%

“…38, 39 Another shortcoming of PFC emulsions is their quite complex formulation, which requires the use of multiple surfactants and microfluidic devices. [39][40][41] As a result, it is difficult to obtain them by industrial production and receive regulatory approval. 42 Promising candidates to serve as fluorinated markers of tumor dissemination process are fluorinated conjugates of proteins.…”

Section: Introductionmentioning

confidence: 99%

Design of protein homocystamides with enhanced tumor uptake properties for 19F magnetic resonance imaging

Chubarov

Zakharova

Koval

et al. 2015

Bioorganic & Medicinal Chemistry

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“…In contrast to the Gd-based agents, for which changes in signal intensity in 1 H MRI originate from water protons in close proximity to the paramagnetic center, 19 F-based contrast agents can directly be detected by 19 (16,17) and in vivo (18)(19)(20)(21)(22)(23)(24)(25), thus far only a limited number of papers have addressed the consequences of cellular association on the 19 F signals (18,26,27). For reliable in vivo quantification, however, it is necessary to know whether cellular binding and internalization influence the relaxometric properties and the linearity of the MR signals with fluorine concentration.…”

Section: Introductionmentioning

confidence: 99%

Quantitative ¹H MRI, ¹⁹F MRI, and ¹⁹F MRS of cell‐internalized perfluorocarbon paramagnetic nanoparticles

Kok¹,

Vries²,

Abdurrachim³

et al. 2011

Contrast Media & Molecular

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In vivo molecular imaging with targeted MRI contrast agents will require sensitive methods to quantify local concentrations of contrast agent, enabling not only imaging-based recognition of pathological biomarkers but also detection of changes in expression levels as a consequence of disease development, therapeutic interventions or recurrence of disease. In recent years, targeted paramagnetic perfluorocarbon emulsions have been frequently applied in this context, permitting high-resolution (1)H MRI combined with quantitative (19)F MR imaging or spectroscopy, under the assumption that the fluorine signal is not altered by the local tissue and cellular environment. In this in vitro study we have investigated the (19)F MR-based quantification potential of a paramagnetic perfluorocarbon emulsion conjugated with RGD-peptide to target the cell-internalizing α(ν)β(3)-integrin expressed on endothelial cells, using a combination of (1)H MRI, (19)F MRI and (19)F MRS. The cells took up the targeted emulsion to a greater extent than nontargeted emulsion. The targeted emulsion was internalized into large 1-7 µm diameter vesicles in the perinuclear region, whereas nontargeted emulsion ended up in 1-4 µm diameter vesicles, which were more evenly distributed in the cytoplasm. Association of the targeted emulsion with the cells resulted in different proton longitudinal relaxivity values, r(1), for targeted and control nanoparticles, prohibiting unambiguous quantification of local contrast agent concentration. Upon cellular association, the fluorine R(1) was constant with concentration, while the fluorine R(2) increased nonlinearly with concentration. Even though the fluorine relaxation rate was not constant, the (19)F MRI and (19)F MRS signals for both targeted nanoparticles and controls were linear and quantifiable as function of nanoparticle concentration.

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19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement

Cited by 26 publications

References 24 publications

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

Design of protein homocystamides with enhanced tumor uptake properties for 19F magnetic resonance imaging

Quantitative ¹H MRI, ¹⁹F MRI, and ¹⁹F MRS of cell‐internalized perfluorocarbon paramagnetic nanoparticles

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19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement

Cited by 26 publications

References 24 publications

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

Design of protein homocystamides with enhanced tumor uptake properties for 19F magnetic resonance imaging

Quantitative 1H MRI, 19F MRI, and 19F MRS of cell‐internalized perfluorocarbon paramagnetic nanoparticles

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Quantitative ¹H MRI, ¹⁹F MRI, and ¹⁹F MRS of cell‐internalized perfluorocarbon paramagnetic nanoparticles