19F-MRT der Lungenventilation in Atemanhaltetechnik mittels SF6-Gas

Schreiber, Laura M.; Markstaller, Klaus; Weiler, Norbert; Eberle, Balthasar; Laukemper-Ostendorf, Simone; Scholz, Alexander; Bürger, Katja; Thelen, M.; Hu, Kauczor

doi:10.1055/s-2000-3750

Cited by 25 publications

(11 citation statements)

References 6 publications

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“…Likewise, but with much less technical effort, ventilation can be visualized using fluorinated gases. This has been demonstrated mainly for SF 6 and C 2 F 6 (11–19). Because of the natural Boltzmann polarization state of these gases, the image quality imposes limits to temporal resolution.…”

mentioning

confidence: 86%

Visualization of inert gas wash‐out during high‐frequency oscillatory ventilation using fluorine‐19 MRI

Wolf

Scholz

Terekhov

et al. 2010

Magnetic Resonance in Med

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High-frequency oscillatory ventilation is looked upon as a lung-protective ventilation strategy. For a further clarification of the physical processes promoting gas transport, a visualization of gas flow and the distribution of ventilation are of considerable interest. Therefore, fluorine-19 magnetic resonance imaging of the imaging gas octafluorocyclobutane (C 4 F 8 ) during high-frequency oscillatory ventilation was performed in five healthy pigs. For that, a mutually compatible ventilation-imaging system was set up and transverse images were acquired every 5 sec using FLASH sequences on a 1.5 T scanner. Despite a drop in signal-to-noise ratio after the onset of high-frequency oscillatory ventilation, for each pig, the four experiments could be analyzed. A mean wash-out time (t) at 5 Hz of 52.7 6 18 sec and 125.9 6 39 sec at 10 Hz, respectively, were found for regions of interest including the whole lung. This is in agreement with the clinical findings, in that washout of respiratory gases is significantly prolonged for increased high-frequency oscillatory ventilation frequencies. Our study could be a good starting-point for a further optimization of high-frequency oscillatory ventilation. Magn Reson Med 64:1479-1483,

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mentioning

confidence: 86%

Visualization of inert gas wash‐out during high‐frequency oscillatory ventilation using fluorine‐19 MRI

Wolf

Scholz

Terekhov

et al. 2010

Magnetic Resonance in Med

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“…of lung cancer, emphysema, or allograft rejection [267][268][269]. Gas detection does require special MR instrumentation, due to the exceedingly short T 1 and T 2 relaxation.…”

Section: Lung Volumementioning

confidence: 99%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

230

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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“…The low spin density of the intrapulmonary gas mixture is compensated by using either a high number of signal averages [17,18] or by increasing the spin density by filling in a fluid compatible with gas exchange [19]. Inert fluorinated gases, such as tetrafluoromethane (CF4), hexafluoroethane (C2F6), or sulfur hexafluoride (SF6), possess a T1 time of the order of milliseconds [17].…”

Section: Fluorine Compoundsmentioning

confidence: 99%

“…The static approach for estimation of the ventilation-perfusion ratio in an animal model with partially obstructed left bronchi was achieved by measuring the ratio of the signal intensity using SF6 in combination with high and low O2 concentration. Imaging within a single breathhold becomes feasible by the use of ultrafast gradientecho sequences [18,21]. Image stacks with a spatial res- (Fig.…”

Section: Fluorine Compoundsmentioning

confidence: 99%

Assessment of lung ventilation by MR imaging: current status and future perspectives

2002

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The aim of this paper is to review the present status of novel MRI techniques as a new important instrument for functional ventilation imaging. The current status and future perspectives in research and clinical applications are summarized. Morphological lung imaging is based on chest radiography and computed tomography, whereas scintigraphy is used for ventilation imaging. During recent years, MRI has emerged as a new means for functional imaging of ventilation. Aerosolized contrast agents and oxygen are used in proton imaging, whereas non-proton imaging relies on fluorine compounds, such as sulfur hexafluoride and perfluorcarbons, or on hyperpolarized noble gases, such as helium-3 or xenon-129. All the gases are administered as inhaled "contrast agents" for imaging of the airways and airspaces. In general, straightforward images demonstrate the homogeneity of ventilation in a breath-hold and allow for determination of ventilated lung. The different properties of the different compounds enable the measurement of additional functional parameters. They comprise airspace size, regional oxygen partial pressure, and analysis of ventilation distribution, ventilation/perfusion ratios, and gas exchange, including oxygen uptake. Novel MRI techniques provide the potential for functional imaging of ventilation. The next steps include definition of the value and the potential of the different contrast mechanisms as well as determination of the significance of the functional information with regard to physiological research and patient management in chronic obstructive pulmonary disease and others.

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19F-MRT der Lungenventilation in Atemanhaltetechnik mittels SF6-Gas

Cited by 25 publications

References 6 publications

Visualization of inert gas wash‐out during high‐frequency oscillatory ventilation using fluorine‐19 MRI

Visualization of inert gas wash‐out during high‐frequency oscillatory ventilation using fluorine‐19 MRI

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Assessment of lung ventilation by MR imaging: current status and future perspectives

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