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Frawley, L.; Devaney, Bridget; Tsouras, Theo; Frawley, Geoff

doi:10.28920/dhm47.1.38-43

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…In mirror, these questions were asked when using pumps in hyperbaric conditions [18–23]. It underline more significant variations with “low” infusion flow rate [18], material-dependent flow variations (tube compliance [21, 22], syringe type [19]), but also during the compression and decompression phases [19, 21, 23]. These phases can be compared to the periods of ascension and descent in flight, with the risk of formation of bubbles, modifying the flows.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of low-weight versus standard syringe infusion pump devices depending on altitude

Blancher

Repellin

Maignan

et al. 2019

Scand J Trauma Resusc Emerg Med

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Background Intravenous drug infusions in critically ill patients require accurate syringe infusion pumps (SIPs). This is particularly important during transportation of critically ill patients by helicopter emergency medical services (HEMS), where altitude may influence device performance. Because weight is a real concern in HEMS, new low-weight devices are very appealing. The aim of this study was to compare infusion flow rates delivered by low-weight versus standard SIP devices, in the prehospital emergency medicine setting, at different altitudes. Methods We conducted a comparative bench study involving five SIP devices (two standard and three low-weight models) at 300, 1700 and 3000 m altitude. The primary endpoint was the flow rate delivered by SIPs for prespecified values. We used two methods to measure flow. The normative method consisted in measuring weight (method A) and the alternate method consisted in measuring instantaneous flow (method B). Results Using method A, no significant differences were found in median flow rates and interquartile range depending on device and altitude for a prespecified 10-mL/h flow. However, method B showed that low-weight SIPs delivered multiple sequential boluses with substantial variations (1.2–15.8 mL/h) rather than a prespecified continuous 5-mL/h flow. At 1700 m altitude, the interquartile range of delivered flows increased only for low-weight devices ( p for interaction< 0.001). Conclusions Despite satisfactory normative tests, low-weight SIPs deliver discontinuous flow with potential clinical implications for critically ill patients receiving vasoactive drugs. This study also highlights a thus far unknown negative impact of altitude on SIP function. We believe that normative requirements for SIP approval should be revised accordingly.

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Section: Discussionmentioning

confidence: 99%

Accuracy of low-weight versus standard syringe infusion pump devices depending on altitude

Blancher

Repellin

Maignan

et al. 2019

Scand J Trauma Resusc Emerg Med

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“…The PMPS system delivers propofol sedation in a way analogous to a commercially available TCI pump when running simulated primary lower-limb arthroplasty procedures. In the simulations made over different patient metrics and target effect-site concentration profiles, the largest difference between the PMPS system and the Perfusor ® Space TCI pump was 0.6 mg in terms of propofol consumed and 0.02 mg/kg/h in terms of dosage; a smaller variation than the tolerance of the commercial device [ 35 ]. Additionally, the inclusion of a laptop allowed an interface to be developed that includes all the data required by the supervising anaesthetist on a single display, reducing mental load and fatigue.…”

Section: Discussionmentioning

confidence: 99%

A Prototype Patient-Maintained Propofol Sedation System Using Target Controlled Infusion for Primary Lower-Limb Arthroplasty

et al. 2019

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Each year, many operations in the UK are performed with the patient awake, without the use of general anaesthesia. These include joint replacement procedures, and in order to reduce patient anxiety, the supervising anaesthetist delivers the sedative propofol intravenously using a target-controlled infusion (TCI) device. However, it is clinically challenging to judge the required effect-site concentration of sedative for an individual patient, resulting in patient care issues related to over or under-sedation. To improve the process, patient-maintained propofol sedation (PMPS), where the patient can request an increase in concentration through a hand-held button, has been considered as an alternative. However, due to the proprietary nature of modern TCI pumps, the majority of PMPS research has been conducted using prototypes in research studies. In this work, a PMPS system is presented that effectively converts a standard infusion pump into a TCI device using a laptop with TCI software. Functionally, the system delivers sedation analogous to a modern TCI pump, with the differences in propofol consumption and dosage within the tolerance of clinically approved devices. Therefore, the Medicines and Healthcare products Regulatory Agency (MHRA) has approved the system as a safe alternative to anaesthetist-controlled TCI procedures. It represents a step forward in the consideration of PMPS as a sedation method as viable alternative, allowing further assessment in clinical trials.

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Safety and performance of intravenous pumps and syringe drivers in hyperbaric environments

Balushi

Smart

2023

Diving Hyperb Med

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Introduction: Critically ill patients require continuation of their care when receiving hyperbaric oxygen treatment. This care may be facilitated via portable electrically powered devices such as intravenous (IV) infusion pumps and syringe drivers, which may create risks in the absence of a comprehensive safety evaluation. We reviewed published safety data for IV infusion pumps and powered syringe drivers in hyperbaric environments and compared the evaluation processes to key requirements documented in safety standards and guidelines. Methods: A systematic literature review was undertaken to identify English language papers published in the last 15 years, describing the safety evaluations of IV pumps and/or syringe drivers for use in hyperbaric environments. Papers were critically assessed in relation to the requirements of international standards and safety recommendations. Results: Eight studies of IV infusion devices were identified. There were deficiencies in the published safety evaluations of IV pumps for hyperbaric use. Despite a simple, published process for evaluating new devices, and available guidelines for fire safety, only two devices had comprehensive safety assessments. Most studies focused only on whether the device functioned normally under pressure and did not consider implosion/explosion risk, fire safety, toxicity, oxygen compatibility or risk of pressure damage. Conclusions: Intravenous infusion (and other electrically powered) devices require comprehensive assessment before use under hyperbaric conditions. This would be enhanced by a publicly accessible database hosting the risk assessments. Facilities should conduct their own assessments specific to their environment and practices.

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Untitled

Cited by 3 publications

References 17 publications

Accuracy of low-weight versus standard syringe infusion pump devices depending on altitude

Accuracy of low-weight versus standard syringe infusion pump devices depending on altitude

A Prototype Patient-Maintained Propofol Sedation System Using Target Controlled Infusion for Primary Lower-Limb Arthroplasty

Safety and performance of intravenous pumps and syringe drivers in hyperbaric environments

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