1H,1′H-[3,3′]biindolyl from the terrestrial fungus Gliocladium catenulatum

One‐Pot Synthesis of Camalexins and 3,3′‐Biindoles by the Masuda Borylation–Suzuki Arylation (MBSA) Sequence

“…3,3′‐Biindoles are scaffolds in natural products such as rivilarine C,17 folicanthine, and chimonanthine 18. In particular, 1 H ,1′ H ‐3,3′‐biindole, a secondary metabolite isolated from the fungus Gliocladium catenulatum ,19 has shown very promising biological activity against Paenibacillus larvae , which is responsible for the American foulbrood disease among honey bees, a significant factor in commercial apiculture due to the lack of specific antibiotic treatment. Furthermore, unsymmetrically substituted 3,3′‐biindoles have been studied for treating protein folding disorder, for example, in Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease, and Creutzfeldt‐Jakob's disease 20…”

Cu(i) catalysis for selective condensation/bicycloaromatization of two different arylalkynes: direct and general construction of functionalized C–N axial biaryl compounds

“…Biaryl compounds that contain an axis and two aryl rings are common chemicals. These structural scaffolds, such as binaphthyls, biindoles, and naphthylindoles, show diverse physical, chemical, and biological properties, 1–8 thus, they are prevalent in natural products, 2 pharmaceuticals, 3 agrochemicals, 4 functional materials, 5 and dyestuffs, 6 as well as ligands 7 and synthetic reagents. 8 In fact, a search in SCI Finder indicates that there are more than 10 000 references with regard to this kind of compound.…”

Syntheses of three naturally occurring polybrominated 3,3′-bi-1H-indoles

“…The only example of a 3,3′-bi-1 H -indole from a terrestrial source is the parent compound isolated from the fungus Gliocladium catenulatum . 9 To the best of our knowledge neither of the polyhalogenated biindoles 1 – 8 have been prepared synthetically to date.…”