1H and 31P benchtop NMR of liquids and solids used in and/or produced during the manufacture of methamphetamine by the HI reduction of pseudoephedrine/ephedrine

Bogun, Ben; Moore, Sarah L.

doi:10.1016/j.forsciint.2017.06.026

Cited by 22 publications

(18 citation statements)

References 8 publications

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“…Organic and P-containing precursor molecules were identified in samples obtained from unregistered, so-called clandestine manufacturing laboratories. LF compact NMR analysis successfully characterised ephedrine, pseudoephedrine, and methamphetamine, whilst also detecting 10 the P-containing precursors used during their synthetic routes [77]. 11 Pharmaceutical and model systems were recently analysed using the first implementation of a DOSY 12 pulse sequence on a LF NMR spectrometer.…”

Section: Structural and Forensic Chemistrymentioning

confidence: 99%

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Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld

Percival

Gibson

et al. 2019

Analytica Chimica Acta

136

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The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free "benchtop" NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively.

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Section: Structural and Forensic Chemistrymentioning

confidence: 99%

“…For the latter class of facilities, in some cases only the direct transference of samples to NMR tubes is required. [77,79]…”

Section: Sample Preparationmentioning

confidence: 99%

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Grootveld

Percival

Gibson

et al. 2019

Analytica Chimica Acta

136

View full text Add to dashboard Cite

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“…A major concern associated with PSE use is illicit drug production. Several chemical methods have been developed to extract and convert PSE into amphetamine (Bogun et al, 2017;Presley et al, 2018). Moreover, additional concerns have been raised based on research findings showing that PSE acts as a sympathomimetic.…”

Section: Discussionmentioning

confidence: 99%

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

Sa-ih¹,

Reakkamnuan²,

Samerphob³

et al. 2020

Acta Neurobiologiae Experimentalis

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The efficacy of pseudoephedrine (PSE) as a nasal decongestant has been well-demonstrated; however, PSE is strictly prescribed as a control substance due to its controversial psychostimulant effects. Although standard stimulatory drugs increase exploratory behavior and stimulate the dopamine system, the exact effects of PSE on locomotion and electrical activity in the striatum have not been determined. This study aimed to examine and compare the locomotor activities, local field potential (LFP) and sleep-wake patterns produced by PSE and morphine, which is a standard drug used to promote psychomotor activity. Male Swiss albino mice were anesthetized and implanted with an intracranial electrode into the striatum. Animals were divided into four groups, which received either saline, PSE or morphine. Locomotor activity and LFP signals were continuously monitored following pseudoephedrine or morphine treatment. One-way ANOVA revealed that locomotor count was significantly increased by morphine, but not PSE. Frequency analyses of LFP signals using fast Fourier transform also revealed significant increases in spectral powers of low-and high-gamma waves following treatment with morphine, but not PSE. Sleep-wake analysis also confirmed significant increases in waking and decreases in both non-rapid eye movement and rapid eye movement sleep following morphine treatment. Sleep-wakefulness did not appear to be disturbed by PSE treatment. These findings indicate that acute PSE administration, even at high doses, does not have psychostimulatory effects and may be relatively safe for the treatment of non-chronic nasal congestion.

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“…Pseudoephedrine and ephedrine can be used as starting materials for methamphetamine (“meth”) synthesis 37 . LF‐NMR spectra (43 MHz) of both ephedrines and methamphetamine were recorded.…”

Section: Lf‐nmr Applicationsmentioning

confidence: 99%

Low‐field benchtop NMR spectroscopy: status and prospects in natural product analysis^†

Beek

2020

Phytochemical Analysis

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Introduction Since a couple of years, low‐field (LF) nuclear magnetic resonance (NMR) spectrometers (40–100 MHz) have re‐entered the market. They are used for various purposes including analyses of natural products. Similar to high‐field instruments (300–1200 MHz), modern LF instruments can measure multiple nuclei and record two‐dimensional (2D) NMR spectra. Objective To review the commercial availability as well as applications, advantages, limitations, and prospects of LF‐NMR spectrometers for the purpose of natural products analysis. Method Commercial LF instruments were compared. A literature search was performed for articles using and discussing modern LF‐NMR. Next, the articles relevant to natural products were read and summarised. Results Seventy articles were reviewed. Most appeared in 2018 and 2019. Low costs and ease of operation are most often mentioned as reasons for using LF‐NMR. Conclusion As the spectral resolution of LF instruments is limited, they are not used for structure elucidation of new natural products but rather applied for quality control (QC), forensics, food and health research, process control and teaching. Chemometric data handling is valuable. LF‐NMR is a rapidly developing niche and new instruments keep being introduced.

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1H and 31P benchtop NMR of liquids and solids used in and/or produced during the manufacture of methamphetamine by the HI reduction of pseudoephedrine/ephedrine

Cited by 22 publications

References 8 publications

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

Low‐field benchtop NMR spectroscopy: status and prospects in natural product analysis^†

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1H and 31P benchtop NMR of liquids and solids used in and/or produced during the manufacture of methamphetamine by the HI reduction of pseudoephedrine/ephedrine

Cited by 22 publications

References 8 publications

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

Low‐field benchtop NMR spectroscopy: status and prospects in natural product analysis†

Contact Info

Product

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Low‐field benchtop NMR spectroscopy: status and prospects in natural product analysis^†