1H HR-MAS NMR and chemometric methods for discrimination and classification of Baccharis (Asteraceae): A proposal for quality control of Baccharis trimera

Dutra, Lívia Macedo; Santos, Alan Diego da Conceição; Lourenço, Allan Vinicius Felix; Nagata, Noemi; Heiden, Gustavo; Campos, Francinete Ramos; Barison, Andersson

doi:10.1016/j.jpba.2020.113200

Cited by 17 publications

(16 citation statements)

References 22 publications

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“…These results are within the range reported by Simões-Pires et al [29] and Besten et al [30] found carquejyl acetate (35.5 to 68% and 40.7 to 73.5%, respectively) as the major compound of EO from B. trimera collected in different places of southern Brazil. Carquejyl acetate is a compound present specifically in the B. trimera species, often differentiating this species with others of the genus Baccharis [31]. Moreover, previous studies reported the antifungal activity and medicinal properties of this compound [17] [18] [31].…”

Section: Resultsmentioning

confidence: 99%

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Atividade antifúngica dos óleos essenciais Baccharis trimera e Foeniculum vulgare para o controle da podridão amarga em maçã

Pedrotti

Magon

Alessio

et al. 2021

RICA

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The present study aimed was to determine the chemical composition of Baccharis trimera and Foeniculum vulgare essential oils (EOs) and their in vitro and in vivo effect against Colletotrichum fructicola, the causal agent of bitter rot in apple. Chemical composition of EOs was determined by GC-MS and their effect against C. fructicola was evaluated in vitro by mycelial growth and conidia germination and in vivo by reducing disease symptoms on postharvest apples. The major compound found in B. trimera EO was carquejyl acetate (74.71%) and in F. vulgare EO was estragole (88.47%). In the in vitro tests, B. trimera EO showed a fungistatic action, while F. vulgare EO presented fungicidal action against mycelial growth. Both EOs showed complete inhibition of conidia germination. In the in vivo assay, both EOs tested were inefficient in reducing disease severity caused by C. fructicola, in preventive and curative treatment. These results are promising and indicate that the EOs might be further investigated as a natural alternative to synthetic fungicides for apple bitter rot control due to its in vitro fungicidal effect.

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Section: Resultsmentioning

confidence: 99%

“…Carquejyl acetate is a compound present specifically in the B. trimera species, often differentiating this species with others of the genus Baccharis [31]. Moreover, previous studies reported the antifungal activity and medicinal properties of this compound [17] [18] [31].…”

Section: Resultsmentioning

confidence: 99%

Atividade antifúngica dos óleos essenciais Baccharis trimera e Foeniculum vulgare para o controle da podridão amarga em maçã

Pedrotti

Magon

Alessio

et al. 2021

RICA

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“…La diferenciación química de B. genistelloides con otras especies de Baccharis está determinada por medio de tres flavonides y AC. Los flavonoides 3-Ometilquercetina, QC y kaempferol permiten diferenciar químicamente a B. genistelloides y B. myriocephala de otras especies del género Baccharis, pero no son considerados sinónimos porque ambas plantas son morfológicamente distintas (Dutra et al 2020). AC es el compuesto químico principal de B. genistelloides que lo diferencia de otras especies, representa el 52,7 % del total del aceite esencial; además, de ser el único marcador fitoquímico de "carqueja" hasta el momento (Chialva & Doglia 1990, Trombin et al 2017.…”

Section: Composición Fitoquímicaunclassified

“…La aplicación de RMN/(HR-MAS) permite una mejor determinación de los compuestos de B. genistelloides, esto debido al análisis que se realiza directamente a la muestra vegetal, sin generar la pérdida de compuestos durante el proceso de extracción; como sucede con la mayoría de los compontes de aceite esencial durante el proceso de hidrodestilación (Augustijn et al 2021, Berka-Zougali et al 2012. Además, permite una mejor autentificación y diferenciación química de B. genistelloides (Dutra et al 2020), en comparación con la técnica de HPLC combinada con metodos quimiométricos SIMCA y KNN (Corsaro et al 2016, Lonni et al 2003.…”

Section: Composición Fitoquímicaunclassified

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Baccharis genistelloides (Lam.) Pers. "carqueja": a review of uses in traditional medicine, phytochemical composition and pharmacological studies

Llaure-Mora

Ganoza-Yupanqui

Suárez-Rebaza

et al. 2021

Ethnobot. Res. App.

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Background: Baccharis genistelloides (Lam.) Pers. "carqueja" is a species native to South America. The best-known synonyms are B. trimera and B. crispa, used mainly against diabetes, obesity, gastrointestinal and liver problems. The objective of this review is to collect information on its uses in traditional medicine, phytochemical composition, and pharmacological studies.Method: 104 papers, 5 books and 11 theses were obtained from different scientific databases and search engines, referring to Baccharis genistelloides and 13 synonyms, between 1996 and 2020, mainly in English.Results: B. genistelloides is traditionally used in diabetes and obesity. More than 107 compounds have been found in its essential oil, with carquejil acetate as the main compound. 12 flavonoids, 8 clerodan diterpenes and 5 derivatives of caffeoylquinic acid have been reported. The most studied pharmacological activities are the antioxidant capacity and the antibacterial effect.Conclusions: Carquejil acetate is the phytochemical marker for B. genistelloides. Rutin, quercetin, βpinene, α-humulene and trans-caryophyllene have pharmacological activity. It is necessary to carry out pharmacological studies to support its traditional use in diabetes and obesity.

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NMR and multivariate methods: Identification of chemical markers in extracts of pedra‐ume‐caá and their antiglycation, antioxidant, and enzymatic inhibition activities

Oliveira,

Pontes,

Acho

et al. 2024

Phytochemical Analysis

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IntroductionIn Brazil, the plant group popularly known as “pedra‐ume‐caá” is used in folk medicine for the treatment of diabetes, and its raw material is commonly sold.ObjectiveThe aim of the study was to apply a method for chemical identification of extracts of dry pedra‐ume‐caá leaves using HPLC–high‐resolution mass spectrometry (HRMS) and NMR and develop a multivariate model with NMR data to authenticate commercial samples. In addition, to evaluate the biological activities of the extracts.Materials and MethodsDry extracts of Myrcia multiflora, Myrcia amazonica, Myrcia guianensis, Myrcia sylvatica, Eugenia punicifolia leaves, and 15 commercial samples (sold in Manaus and Belém, Brazil) were prepared by infusion. All the extracts were analysed using HPLC–high‐resolution mass spectrometry (HRMS), NMR, principal component analysis (PCA), and hierarchical cluster analysis (HCA). The antidiabetic effect of extracts was evaluated according to enzymatic inhibition. Their content of total phenols, cell viability, and antioxidant and antiglycation activities were also determined.ResultsHPLC‐HRMS and NMR analysis of these extracts permitted the identification of 17 compounds. 1H NMR data combined with multivariate analyses allowed us to conclude that catechin, myricitrin, quercitrin, and gallic and quinic acids are the main chemical markers of pedra‐ume‐caá species. These markers were identified in 15 commercial samples of pedra‐ume‐caá. Additionally, only the extracts of M. multiflora and E. punicifolia inhibited α‐glucosidase. All the extracts inhibited the formation of advanced glycation end products (AGEs) and showed free‐radical‐scavenging activity. These extracts did not present cytotoxicity.ConclusionThis study revealed the chemical markers of matrices, and it was possible to differentiate the materials marketed as pedra‐ume‐caá. Moreover, this study corroborates the potential of these species for treating diabetes.

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1H HR-MAS NMR and chemometric methods for discrimination and classification of Baccharis (Asteraceae): A proposal for quality control of Baccharis trimera

Cited by 17 publications

References 22 publications

Atividade antifúngica dos óleos essenciais Baccharis trimera e Foeniculum vulgare para o controle da podridão amarga em maçã

Atividade antifúngica dos óleos essenciais Baccharis trimera e Foeniculum vulgare para o controle da podridão amarga em maçã

Baccharis genistelloides (Lam.) Pers. "carqueja": a review of uses in traditional medicine, phytochemical composition and pharmacological studies

NMR and multivariate methods: Identification of chemical markers in extracts of pedra‐ume‐caá and their antiglycation, antioxidant, and enzymatic inhibition activities

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