1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet

Comparative metabolomics analysis on invigorating blood circulation for herb pair Gui-Hong by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and pattern recognition approach

“…To illustrate the identification of metabolites, we took the ion at t R = 4.28 min, m/z 161.1559) as an example to be described below. This ion might contain an odd number of nitrogen atoms because its precise molecular weight was 161.1559, and its molecular formula was speculated to be C 6 Finally, to define its structure, according to the standard references and HMDB database, the metabolite was identified as aminoadipic acid.…”

“…It is an ancient and classic formula comprised of DG and HH, which has the activating blood circulation and dissipating blood stasis effects. GH is often used in traditional Chinese medicine prescriptions in clinic, such as Tao-Hong-Si-Wu Decoction, Xue-Fu-Zhu-Yu Decoction, Bu-Yang-Huan-Wu Decoction and et al [6].…”

Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan

“…According to a previous study, Xue-Fu-Zhu-YuTang has been reported to induce endothelial progenitor cell angiogenesis and hasten tube formation, particularly in capillary vessels, and to potentiate rt-PA-mediated neuroprotection against thromboembolic stroke in rats . In an animal model, Xue-Fu-Zhu-Yu-Tang restored the abnormal metabolic state by interfering with various metabolic pathways to induce partial reverse of energy and lipid metabolism disturbance and decrease the risk of ketoacidosis, atherosclerosis, and fatty liver disease induced by a high-fat diet; these authors concluded that these effects might be due to the antihyperlipidemia, antioxidation, and antiinflammatory activities of its components (Song et al, 2013).…”

Effects of Hyulboochucke-tang on the Collagenase-Induced Intracerebral Hemorrhage in Rats

“…혈부축어탕에 대한 실험 연구로는 심근경색 재관류 효 과 8) , 고지질혈증 억제 효과 9,10) , 죽상경화증 억제 효과 11) , 전뇌허혈로 인한 신경세포 손상 보호 효과 12) , 모세혈관에서 내피 줄기세포의 혈관 형성 촉진 효과 13) , 혈전색전증으로 뇌경색이 유발된 흰쥐에서 신경세포손상 보호 효과 14,15) , 리를 희생하여 검사에 이용하였다.…”