1q translocations (unbalanced) in myeloid malignancies

Abstract

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Isolated 1q21 rearrangement der(20)t(1;20)(q21;p13) with telomere involvement of 20p in a case of longstanding myelodysplastic syndrome

“…Der 20t(1;20)(q21;p13) belongs to the group of the unbalanced 1q12-21 translocations observed mostly as a second genetic event in a large spectrum of hematological malignances (Zamecnikova A and Al, Bahar S. 2013). Unbalanced 1q12-21 translocations affecting 20p have been reported in 10 cases: 6 with multiple myeloma (Fiedler et al, 1992;Taniwaki et al, 1994;Keung et al, 1998;Sawyer et al, 1998;Mohamed et al, 2007;Sawyer et al, 2014), 1 with acute lymphoblastic leukemia/ lymphoblastic lymphoma (Wan et al, 2004), 1 with diffuse large Bcell lymphoma (Levine et al, 1985), 1 with acute myeloid leukemia (M7) (Yoshida et al, 2013) and 1 with chronic myeloproliferative disorder (L'Abbate et al, 2015).…”