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Amin, Mahul B.; Edge, Stephen B.; Greene, Frederick L.; Byrd, David R.; Brookland, Robert K.; Washington, Mary Kay; Gershenwald, Jeffrey E.; Compton, Carolyn C.; Hess, Kenneth R.; Sullivan, Daniel C.; Jessup, J. Milburn; Brierley, James D.; Gaspar, Laurie E.; Schilsky, Richard L.; Balch, Charles M.; Winchester, David P.; Asare, Elliot A.; Madera, Martin; Gress, Donna M.; Meyer, Laura; Gaspar, Lauri E.

doi:10.1007/978-3-319-40618-3_2

Cited by 2,217 publications

(3,367 citation statements)

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“…According to the 8th edition of the AJCC Cancer Staging Manual2 published in 2017, Tis is defined as carcinoma in situ/high‐grade dysplasia. The definition of Tis has been expanded to include high‐grade biliary intraepithelial neoplasia (BilIN‐3), which is a non‐invasive neoplastic process, that is synonymous with carcinoma in situ 2.…”

Section: “Carcinoma In Situ”: Histopathological Terminologymentioning

confidence: 99%

“…The definition of Tis has been expanded to include high‐grade biliary intraepithelial neoplasia (BilIN‐3), which is a non‐invasive neoplastic process, that is synonymous with carcinoma in situ 2. Tumors classified as Tis cytologically resemble carcinoma, with diffuse and severe distortion of cellular polarity, but invasion through the basement membrane is absent.…”

Section: “Carcinoma In Situ”: Histopathological Terminologymentioning

confidence: 99%

“…Surgical resection with curative intent provides the best chance of cure and long‐term survival in patients with resectable extrahepatic cholangiocarcinoma 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. Recent advances in dimensional imaging, perioperative management, including biliary drainage and percutaneous transhepatic portal vein embolization, and surgical technique have resulted in increased rates of complete resection with histopathologically negative margins and improved patient survival in patients with extrahepatic cholangiocarcinoma 3, 4, 5, 6.…”

Section: Introductionmentioning

confidence: 99%

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Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma

Wakai

Sakata

Katada

et al. 2018

Annals of Gastroent Surgery

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Recent advances in dimensional imaging, surgical technique, and perioperative patient care have resulted in increased rates of complete resection with histopathologically negative margins and improved surgical outcomes in patients with extrahepatic cholangiocarcinoma. However, achieving cancer‐free resection margins at ductal stumps in surgery for this disease remains challenging because of longitudinal extension, which is one of the hallmarks of extrahepatic cholangiocarcinoma. When the ductal resection margins are shown to be positive on examination of frozen sections, discrimination between carcinoma in situ and invasive carcinoma is clinically important because residual carcinoma in situ may lead to late local recurrence whereas residual invasive carcinoma is associated with early local recurrence. Residual invasive carcinoma at the ductal margins should be avoided whenever technically feasible. Residual “carcinoma in situ” at the ductal margins appears to be allowed in resection for the advanced disease because it has less effect on survival than other adverse prognostic factors (pN1 and/ or pM1). However, in surgery for early‐stage (pTis‐2N0M0) extrahepatic cholangiocarcinoma, residual carcinoma in situ at the ductal margins may have an adverse effect on long‐term survival, so should be avoided whenever possible. In this review, we focus on the histopathological term “carcinoma in situ,” the biological behavior of residual carcinoma in situ at ductal resection margins, intraoperative histological examination of the ductal resection margins, outcome of additional resection for positive ductal margins, and adjuvant therapy for patients with positive margins.

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Section: “Carcinoma In Situ”: Histopathological Terminologymentioning

confidence: 99%

Section: “Carcinoma In Situ”: Histopathological Terminologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma

Wakai

Sakata

Katada

et al. 2018

Annals of Gastroent Surgery

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“…Other studies confirmed the same finding which suggested that targeted treatments with selective BRAF inhibitors (vemurafenib and dabrafenib that were shown to improve overall and progression-free survival in cutaneous melanomas) are not of use in mucosal melanomas, especially in the head and neck site [34][35][36] . The new staging system according to the 8 th Edition of the American Joint Committee on Cancer (AJCC) 37 established a novel approach on T, N and M categories. Thus, only the T3, T4a and T4b categories are maintained, similar to the 7 th edition of AJCC, omitting T1 and T2 categories because of the very poor prognosis for small, superficial lesions (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the N category, the cervical lymph nodes are the primary lymphatic drainage, but due to the rarity of this disease, nodal metastasis are currently classified in present (N1) or absent (N0). The role of extranodal extension (ENE) is not yet established 37 . Distant metastases (M1) are usually common at clinical presentation and are usually located in lung and liver (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Primary sinonasal mucosal melanoma – Case report and literature review

Evsei

Birceanu-Corobea

Melinte

et al. 2017

Romanian Journal of Rhinology

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BACKGROUND. Primary sinonasal mucosal melanoma is a rare tumor with a poor survival rate. There is an inherent difficulty in diagnosing these lesions, especially because their complex anatomic locations and symptoms can be frequently confused with other benign or malignant processes. The purpose of our study was to report a difficult case and review the literature and recent research on therapeutic modalities. MATERIAL AND METHODS. We herein report a 61-year-old female patient, with a history of right eye enucleation and prosthesis, who presented with obstruction of the left nostril, anterior and posterior mucopurulent rhinorrhea, anosmia, left facial numbness, left exophthalmia accompanied by ipsilateral epiphora and decreased visual acuity. RESULTS. Clinical and imagistic testing revealed a large, grayish, fleshy tumor localized in the left maxillary sinus, with extension to the left orbit (producing osteolysis of the inferior and medial orbital walls), nasopharynx, ethmoidal cells and left frontal sinus. Pathological and immunohistochemical examination confirmed the diagnosis of mucosal melanoma. Other primary sites were excluded. The patient succumbed shortly after, following only palliative treatment. CONCLUSION. Early diagnosis of primary sinonasal mucosal melanoma is essential but very difficult to detect. Any symptoms such as unilateral epistaxis or nasal obstruction in a patient over the age of 60 should be rendered suspicious. Pathological and immunohistochemical examination for diagnosis and prognostic factors are important. Although surgery is the first option for treatment, one must consider, according to tumor staging, radiotherapy and chemotherapy with immunotherapy as a viable course of treatment for advanced cases.

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Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening

Comstock

Gatsonis

Newstead

et al. 2020

JAMA

326

162

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Importance: Improved screening methods for women with dense breasts are needed because of their increased risk of breast cancer and of failed early diagnosis by screening mammography. Objective: To compare the screening performance of abbreviated breast MRI (AB-MR), and digital breast tomosynthesis (DBT) in women with dense breasts. Design, Setting, and Participants: Cross-sectional study with longitudinal follow-up at 48 academic, community hospital, and private practice sites in the US and Germany, conducted between December 2016 and November 2017, that included average-risk women aged 40-75 years with heterogeneously dense or extremely dense breasts undergoing routine screening. Follow up ascertainment of cancer diagnoses was complete through September 12 th , 2019. Exposure: All women underwent screening by both DBT and AB-MR, performed in randomized order and read independently to avoid interpretation bias. Main outcome measures: The primary endpoint was the invasive cancer detection rate. Secondary outcomes included sensitivity, specificity, the additional-imaging-recommendation-rate, and positive predictive value (PPV) of biopsy, using invasive cancer and DCIS to define a positive reference standard. All outcomes are reported at the participant level. Pathology of core or surgical biopsy was the reference standard for cancer detection rate and PPV; interval cancers reported until the next annual screen were included in the reference standard for sensitivity and specificity. Results: Among 1516 enrolled women, 1444 (median age 54, range 40-75) completed both examinations and were included in the analysis. The reference standard was positive for invasive cancer with or without DCIS in 17 women, and for DCIS alone in another 6. No interval cancers were observed during follow-up. AB-MR detected all 17 women with invasive cancer, and 5/6 women with DCIS. DBT detected 7/17 women with invasive cancer, and 2/6 women with DCIS. The invasive-cancer-detection-rate was 11.8 per 1000 women [95% CI 7.4-18.8] for AB-MR versus 4.8 per 1000 women [95% CI 2.4-10.0] for DBT, a difference of 7 per 1000 women [95% CI for the difference 2.2-11.6] (exact McNemar p=0.002). For detection of invasive cancer and Comstock et al.

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Cited by 2,217 publications

References 0 publications

Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma

Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma

Primary sinonasal mucosal melanoma – Case report and literature review

Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening

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