2022
DOI: 10.1002/tox.23685
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1α,25‐dihydroxyvitamin D3 supplementation alleviates perfluorooctanesulfonate acid‐induced reproductive injury in male mice: Modulation of Nrf2 mediated oxidative stress response

Abstract: Perfluorooctanesulfonate acid (PFOS) is a typical persistent organic pollutant that widely exists in the environment. To clarify the toxic effects and mechanisms of PFOS and to find effective intervention strategies have been attracted global attention. Here, we investigated the effects of PFOS on the male reproductive system and explored the potential protective role of 1α,25-dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ).Our results showed that 1α,25(OH) 2 D 3 intervention significantly improved PFOSinduced sperm q… Show more

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Cited by 6 publications
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“…5 In addition, PFOS induces astrocyte apoptosis and alters the dopamine system in mammals, leading to neurotoxicity. 6,7 For the human and animal reproductive systems, PFOS can cause reproductive toxicity by reducing the quality of germ cells, 8 and disrupting the normal structure of reproductive organs and embryonic development. 9,10 Experiments in animals and in vitro have as well shown the oxidative effects and toxicity of PFOS on tissues and cells, resulting in multiple organs (e.g., kidney, liver, heart, and lung) with severe damage.…”
mentioning
confidence: 99%
“…5 In addition, PFOS induces astrocyte apoptosis and alters the dopamine system in mammals, leading to neurotoxicity. 6,7 For the human and animal reproductive systems, PFOS can cause reproductive toxicity by reducing the quality of germ cells, 8 and disrupting the normal structure of reproductive organs and embryonic development. 9,10 Experiments in animals and in vitro have as well shown the oxidative effects and toxicity of PFOS on tissues and cells, resulting in multiple organs (e.g., kidney, liver, heart, and lung) with severe damage.…”
mentioning
confidence: 99%