2,2,2-trifluoro-1-(1,4,5,6-tetrahydropyridin-3-yl)ethanone derivative as efflux pump inhibitor in Mycobacterium tuberculosis

This review describes advances in the synthesis of heterocyclic scaffolds (associated with their biological activity), using haloacetylated enol ethers as precursors. The wide variety of heterocycles that can be prepared using these precursors, together with the high regioselectivity they usually provide, in [3+2] and [3+3] cyclocondensation reactions, make these starting materials powerful tools. The biological evaluation is also highlighted, given that several analogues of commercially available drugs can be easily accessed.

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Haloacetylated Enol Ethers: a Way Out for the Regioselective Synthesis of Biologically Active Heterocycles

Mittersteiner

Martins

Zanatta

2021

Eur J Org Chem

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One-pot synthesis of difluoromethyl-containing 1,2,3,4-tetrahydropyridines

Gibadullina

Kireeva

Лобов

et al. 2023

Journal of Fluorine Chemistry

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An environmentally friendly method for the synthesis of 1,2,3,4-tetrahydropyridines and hexahydroimidazo[1,2-a]pyridines in water promoted by potassium, sodium and ammonium chlorides

Gibadullina,

Mukhamedyarova,

Lobov

et al. 2024

Tetrahedron Letters

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2,2,2-trifluoro-1-(1,4,5,6-tetrahydropyridin-3-yl)ethanone derivative as efflux pump inhibitor in Mycobacterium tuberculosis

Cited by 4 publications

References 28 publications

Haloacetylated Enol Ethers: a Way Out for the Regioselective Synthesis of Biologically Active Heterocycles

Haloacetylated Enol Ethers: a Way Out for the Regioselective Synthesis of Biologically Active Heterocycles

One-pot synthesis of difluoromethyl-containing 1,2,3,4-tetrahydropyridines

An environmentally friendly method for the synthesis of 1,2,3,4-tetrahydropyridines and hexahydroimidazo[1,2-a]pyridines in water promoted by potassium, sodium and ammonium chlorides

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