2-2) Behavioral Teratogenicity of Methamphetamine

Cho, Dae‐Hyun; Lyu, Hang-mook; Lee, Hae-bin; Kim, Pu-young; Chin, Kang

doi:10.2131/jts.16.supplementi_37

Cited by 42 publications

(40 citation statements)

References 12 publications

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“…On the other hand, the present study demonstrates that pups prenatally exposed to M opened their eyes later than controls or saline-exposed pups. This finding is in agreement with the work of Cho, Lyu, Lee, Kim, and Chin (1991) and Martin (1975), while it is in contrast with the data of Weissman and Caldecott-Hazard (1993). Further, Vorhees (1985) showed that the .5 mg/kg amphetamine group showed delayed eye opening, but the 2.0 mg/kg group did not.…”

Section: Discussionsupporting

confidence: 81%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

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The present study tested the hypothesis that cross-fostering influences the development of rat pups. Mothers were exposed daily to injection of methamphetamine (M) (5 mg/kg) or saline for 9 weeks: 3 weeks prior to impregnation, throughout gestation and lactation periods. Control females animals without any injections were used. On postnatal day (PD) 1, pups were cross-fostered so that each mother received four pups of her own and eight pups from the mothers with the other two treatments. Offspring were tested for sensorimotor development in preweaning period by using tests of: negative geotaxis, tail pull, righting reflexes, rotarod and bar-holding. Further, the pups were weighed daily. Our results showed that birth weight in prenatally M-exposed pups was lower than in control or saline-exposed pups. Prenatally M-exposed pups gained less weight than control or saline-exposed pups regardless of postnatal treatment and sex. Further, our data demonstrated that prenatal and postnatal M exposure impairs sensorimotor functions in most of the tests. On the other hand, the negative effect of prenatal M exposure was partially suppressed in prenatally M-exposed pups by cross-fostering to control dams. Our hypothesis that cross-fostering may affect postnatal development of pups was confirmed.

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Section: Discussionsupporting

confidence: 81%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

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“…Moreover, our previous finding demonstrating that rat pups exposed prenatally to daily dose of 5 mg/kg of MA impairs their locomotor activity (Š lamberová et al, 2006). There are studies showing that this dose results in fetal brain drug concentrations, which approximate those reported in human infants whose mothers abuse MA (Acuff-Smith, Schilling, Fisher, & Vorhees, 1996;Cho, Lyu, Lee, Kim, & Chin, 1991;Martin, Martin, Radow, & Sigman, 1976;Won, Bubula, McCoy, & Heller, 2001;Yamamoto, Yamamoto, Fukui, & Kurishita, 1992). The concentration of the solution was 10 mg/ml, thus, each animal received the amount of .5 ml/kg of the solution.…”

Section: Prenatal and Preweaning Treatmentmentioning

confidence: 65%

Effect of methamphetamine exposure during prenatal and preweaning periods lasts for generations in rats

Šlamberová

Pometlová

Rokyta

2007

Developmental Psychobiology

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Our previous studies demonstrated that methamphetamine (MA) administration during gestation and/or lactation affects maternal behavior in rats and that birth weight and sensory-motor coordination of their pups are also influenced. The present study tested the hypothesis that the effect of MA induces long-term changes affecting second generation of rats that were not exposed to the drug. Adult females exposed during prenatal and preweaning periods to 5 mg/kg MA daily, were examined for regularity of estrous cycle and mated with stimulus, unexposed males. Dams (nontreated absolute control, saline- and MA-exposed) were observed with their pups in two tests of maternal behavior (observational and retrieval tests). Their pups were further tested throughout the preweaning period to examine their development. Our data demonstrate that MA-exposed mothers displayed more nursing, were more often in the nest and in contact with their pups, and were faster in retrieving their pups than saline-exposed and/or control mothers. There were no differences in litter characteristics, birth weight and weight gain of pups between groups. Interestingly, pups from mothers exposed to MA during prenatal and preweaning period had impaired sensory-motor coordination. They achieved righting reflex in mid-air later than both control groups. Additionally, they had more falls in rotarod and bar-holding tests than pups from both control and saline-exposed mothers. In homing performance, pups from MA- and saline-exposed dams learned slower to return to the home box than pups from control dams. Thus, the present study demonstrates that MA abused by mothers may affect two generations of their offspring.

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“…Lower dose MA exposure during preand postnatal development (5 mg/kg x 2 per day) has been reported by others to produce increased running wheel activity when tested once per month beginning at the age of 1 3 months and continuing to 35 months of age (Martin et al 1976;Martin and Martin 1981). More recently, Cho et al (1991) found that prenatal MA exposure (1-4.5 mg/kg) produced increased locomotor activity in the offspring. Although running wheel activity may not be directly comparable to briefer activity measurements (which reflect primarily exploration and habituation), the available data are generally consistent in finding that prenatal MA exposure leads to increased activity.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine exposure during early postnatal development in rats: II. Hypoactivity and altered responses to pharmacological challenge

et al. 1994

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Methamphetamine induces neurotransmitter reductions and neurotoxicity at high doses in adult animals, but its effects on early brain development and behavior have received little attention. In this experiment the effects of methamphetamine exposure during a period equivalent to the human third trimester were examined. Rats (Sprague-Dawley CD) were injected subcutaneously with d-methamphetamine (d-MA) (30 mg/kg b.i.d.) early in postnatal development (days 1-10), later (postnatal days 11-20), or with water during both of these periods. Both early and later MA-exposed offspring exhibited reduced locomotor activity. The effect was most evident at 30 days of age and was smaller at 45 and 60 days and only present at these latter ages in males. Only the early MA exposure group showed prolonged suppression of activity in response to a challenge dose of fluoxetine and a persistent deficit in weight while only the later MA exposure group showed attenuated suppression of activity in response to a challenge dose of fluoxetine. Based both on the present data and those in the preceding article, it was concluded that the effects of MA are both long lasting and stage dependent and involve arousal as well as cognitive functions.

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2-2) Behavioral Teratogenicity of Methamphetamine

Cited by 42 publications

References 12 publications

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Effect of methamphetamine exposure during prenatal and preweaning periods lasts for generations in rats

Methamphetamine exposure during early postnatal development in rats: II. Hypoactivity and altered responses to pharmacological challenge

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