2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds

doi:10.21608/ejchem.2012.1427

Egypt. J. Chem.

2012

DOI: 10.21608/ejchem.2012.1427

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2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds

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Cited by 2 publications

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Microwave‐ultrasonic assisted synthesis, and characterization of novel 3′‐(amino, hydrazino and hydrazide)‐6′‐bromo‐spiro(isobenzofuran‐1,2′‐quinazoline)‐3,4′‐dione derivatives as antimicrobial agents

Algohary

Hassan

Rizk

2023

Journal of Heterocyclic Chem

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By attempts to construct new antimicrobial agents, a series of mono-and dibromo of 3 0 -(oxiranyl, hydrazide, oxadiazolo and pyrazolo)-methylene-spiro [isobenzofuran-1,2 0 -quinazoline]-3,4 0 (3 0 H)-dione derivatives were synthesized through the interaction between 6-bromo and/or 6,8-dibromo-spiroiso-benzofuran-1,2 0 -quinazolindione with carbon electrophiles, namely, ethyl chloroacetate, epichlorohydrin, chloroacetyl chloride and phosphorus pentasulfide (P 2 S 5 ). Reaction of ethylester of spiroquinazolindione with hydrazine hydrate under MW-US and UV reaction condition (green tool saves time and energy) to afford spiroquinazolindione hydrazide that used as preparatory materials for the synthesis of novel spiroquinazolin-dione. Most of the created compounds were evaluated in vitro for their antibacterial and antifungal activity.The 6-bromo or 6,8-dibromo quinazolin-3,4-dione nucleus bears oxirane hydrazino acetyl, hydrazide, oxadiazole and pyrazole moieties at position (3) and were the most potent against the gram-positive bacteria, gram-negative bacteria, and fungi comparable to Chloramphenicol and Fluconazole.

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Microwave‐ultrasonic assisted synthesis, and characterization of novel 3′‐(amino, hydrazino and hydrazide)‐6′‐bromo‐spiro(isobenzofuran‐1,2′‐quinazoline)‐3,4′‐dione derivatives as antimicrobial agents

Algohary

Hassan

Rizk

2023

Journal of Heterocyclic Chem

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Utilization derivatives of 4 - [4-(acetylamino)phenyl]-2 - (3,5 dimethyl - 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid in Heterocyclic Synthesis and Study of Their Biological Activities

Aburzeza¹,

Alfalous²

2020

JAU

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The aim of this research the derivatives of 4- [4-(acetylamino) phenyl]- 2 -(3,5dimethyl- 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid was used synthesize heterocyclic compounds. These heterocyclic compounds could be used as the main feedstock to prepare heterocyclic compounds (6,5 membred ring) including thiadiazolo, imidazole and pyridazinone derivatives. The effect of nucleophilic and electrophilic reagents on the resulting pyridazinones compounds was studied. Through preliminary analyzes of the compounds prepared in the research and spectroscopic data which obtained their structures were proved, and it have biological activities.

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2- (3, 4- Dimethylphenyl - 3- [3, 4-Dichloro (or 3, 4-Dimethyl) Benzoyl])-Propanoic Acids as Precursors in the Synthesis of Some Heterocyclic Compounds

Cited by 2 publications

References 17 publications

Microwave‐ultrasonic assisted synthesis, and characterization of novel 3′‐(amino, hydrazino and hydrazide)‐6′‐bromo‐spiro(isobenzofuran‐1,2′‐quinazoline)‐3,4′‐dione derivatives as antimicrobial agents

Microwave‐ultrasonic assisted synthesis, and characterization of novel 3′‐(amino, hydrazino and hydrazide)‐6′‐bromo‐spiro(isobenzofuran‐1,2′‐quinazoline)‐3,4′‐dione derivatives as antimicrobial agents

Utilization derivatives of 4 - [4-(acetylamino)phenyl]-2 - (3,5 dimethyl - 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid in Heterocyclic Synthesis and Study of Their Biological Activities

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