2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation

Han, Xin; Ling, Shuang; Gan, Woting; Sun, Li; Duan, Ju; Xu, Jin-Wen

doi:10.1016/j.atherosclerosis.2012.08.011

Cited by 48 publications

(38 citation statements)

References 29 publications

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“…TSG has received a great deal of attention owing to its biological properties, including antioxidative and anti-inflammatory effects [6,7]. TSG has been shown in various studies to inhibit matrix metalloproteinases activation, inflammation and vascular endothelial dysfunction in atherosclerotic rats [8,9]; reduce proliferation of vascular smooth muscle cells, oxidation of lipoprotein, vascular senescence and endothelial senescence [10,11,12,13]. However, whether TSG can inhibit oxLDL-induced experimental endothelial dysfunction remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

Yao

Huang²,

Sun³

et al. 2014

Cell Physiol Biochem

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Background: Endothelial cell dysfunction triggered by oxidized low-density lipoprotein (oxLDL) is the main event occurring during the development of atherosclerosis. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component of the rhizome extract from Polygonum multiflorum, exhibits significant anti-atherosclerotic activity. However, the protective effects of TSG against oxLDL-induced endothelial dysfunction have not been clarified. We investigated the cytoprotective effects of TSG in human umbilical vein endothelial cells (HUVECs) and explored underlying mechanisms. Methods and Results: TSG pretreatment markedly attenuated oxLDL-mediated loss of cell viability, release of lactate dehydrogenase (LDH), cell apoptosis, and monocyte adhesion. OxLDL increased vimentin mRNA and protein levels, vimentin cleavage, caspase-3 activation, adhesion molecules levels and their colocalization with vimentin in HUVECs. These alterations were attenuated by pretreatment with TSG. Meanwhile, TSG inhibited both the expression of TGFβ1 and the phosphorylation of Smad2 and Smad3, and TSG suppressed the nuclear translocation of Smad4 induced by oxLDL. Using shRNA, oxLDL-induced cell apoptosis and monocyte adhesion were significantly inhibited by vimentin suppression in HUVECs. Conclusions: These results suggest that TSG protects HUVECs against oxLDL-induced endothelial dysfunction through inhibiting vimentin expression and cleavage, and the expression of adhesion molecules and their colocalization with vimentin. The interruption of TGFβ/Smad pathway and caspase-3 activation appears to be responsible for the downregulation of TSG on vimentin expression and fragmentation, respectively.

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Section: Introductionmentioning

confidence: 99%

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

Yao

Huang²,

Sun³

et al. 2014

Cell Physiol Biochem

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“…For a good illustration of the fundamental role of tonifying kidney, as shown in Table 1, we summarize 10 common Chinese medical herbs for tonifying kidney and sum up their pharmacological activities. showed that THSG inhibited vascular aging [50] and regulated the expression of klotho, especially in the brain, testis, and kidney [47]. It also has the therapeutic benefits in bone diseases.…”

Section: Reinforcing Kidney Drugs and Diseasesmentioning

confidence: 99%

The Connotation of Kidney Stores Essence Theory and Kidney Endocrine Substance

Ling¹,

Dang²,

Ni³

et al. 2017

Chinese Medical Therapies for Diabetes, Infertility, Silicosis and the Theoretical Basis

Self Cite

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Traditional Chinese medicine (TCM) is a traditional healing system with unique theoretical system. The Zang-Fu theory is the closest mapping to body's physiological and pathological changes. Kidney is the most vital Zang organ in TCM system. However, the material basis of kidney essence is still undefined. In this chapter, we propose the idea that kidney endocrine substances, such as renin, kallikrein, erythropoietin (EPO), calcitriol, bone morphogenetic protein (BMP)-7, and klotho, are potential candidates of the material basis of kidney essence. In addition, kidney-nourishing therapy and related Chinese medicinal herbs are also introduced.

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“…In addition, endothelial senescence in the spontaneously hypertensive rat model was decreased with treatment with a SIRT1 activator. This treatment correlated with a decrease in p53 acetylation and increased NOS3 transcription (Han et al 2012). …”

Section: Role Of P53 and Sirt1 In Regulating Senescence Of The Vasculmentioning

confidence: 99%

Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction

Northcott

Czubryt

Wigle

2017

Can. J. Physiol. Pharmacol.

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2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation

Cited by 48 publications

References 29 publications

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

Tetrahydroxystilbene Glucoside Protects Against Oxidized LDL-Induced Endothelial Dysfunction via Regulating Vimentin Cytoskeleton and its Colocalization with ICAM-1 and VCAM-1

The Connotation of Kidney Stores Essence Theory and Kidney Endocrine Substance

Vascular senescence and ageing: a role for the MEOX proteins in promoting endothelial dysfunction

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