2005
DOI: 10.1016/j.taap.2004.12.003
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: A microarray study

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Cited by 151 publications
(116 citation statements)
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“…In the present study, a significant decrease in Na (Jabs et al 1989;Schwartzman et al 1985;Lear et al 1990;Therien and Blostein 2000). In addition, altered expression of Na + K + -ATPase in hepatic tissues during TCDD treatment has been reported earlier by Fletcher et al (2005) and Peterson et al (1979).…”
Section: Discussionsupporting
confidence: 86%
“…In the present study, a significant decrease in Na (Jabs et al 1989;Schwartzman et al 1985;Lear et al 1990;Therien and Blostein 2000). In addition, altered expression of Na + K + -ATPase in hepatic tissues during TCDD treatment has been reported earlier by Fletcher et al (2005) and Peterson et al (1979).…”
Section: Discussionsupporting
confidence: 86%
“…Because TCDD did not have any effect on the hepatic expression of BSEP and MRP2, it is suggested that one of the mechanisms underlying the elevated level of bile acids in the feces is attenuated resorption in the small intestine rather than excess release from the liver. Also, in accordance with a previous report, 25) TCDD reduced or tended to reduce the hepatic expression of CYP7A1 and NTCP. CYP7A1 oxidizes cholesterol to its 7-hydroxy derivative, a rate-limiting step in bile acid synthesis, and NTCP is involved in the enterohepatic circulation of bile acids: that is, this protein transports bile acids back to the liver.…”
Section: Discussionsupporting
confidence: 93%
“…In this context, a previous study using a DNA microarray analysis also suggested that TCDD alters the hepatic expression of genes associated with the metabolism of cholesterol, and the biosynthesis and transport of bile acids. 25) As established already, bile acids play an important role in the intestinal absorption of lipids and cholesterol, [26][27][28] steroid metabolism 29) and the biliary secretion of lipids and xenobiotics. 30) Therefore, an excess of bile acids may be linked to TCDD-produced wasting syndrome and the impaired utilization of lipids.…”
mentioning
confidence: 99%
“…Activation of Ahr by those drugs induces the transcription of genes containing XRE sites in their promoter regions (1,4). Known Ahr targets include loci encoding cytochrome P450 family members in charge of the phase I detoxification response (5-9), phase II detoxification proteins (10 -12), metabolism-related enzymes (13)(14)(15), and many other molecules (16,17).…”
mentioning
confidence: 99%