2016
DOI: 10.1016/j.ajem.2016.03.025
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2,3-Butanedione monoxime facilitates successful resuscitation in a dose-dependent fashion in a pig model of cardiac arrest

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Cited by 6 publications
(19 citation statements)
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“…The anaesthesia and animal preparation techniques used in this study have been previously described in detail . After endotracheal intubation, the animals were mechanically ventilated, using an anaesthesia machine with a tidal volume of 10 mL/kg and a respiratory rate adjusted to achieve normocapnia.…”
Section: Methodsmentioning
confidence: 99%
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“…The anaesthesia and animal preparation techniques used in this study have been previously described in detail . After endotracheal intubation, the animals were mechanically ventilated, using an anaesthesia machine with a tidal volume of 10 mL/kg and a respiratory rate adjusted to achieve normocapnia.…”
Section: Methodsmentioning
confidence: 99%
“…Instead, a 5.0‐F thermistor‐tipped catheter (VolumeView ™ femoral arterial catheter; Edwards Lifesciences) was inserted via the right femoral artery for haemodynamic measurements using a transpulmonary thermodilution technique. For echocardiographic assessments of LV function, a transoesophageal echocardiography probe (UST‐5293‐5; Hitachi Aloka Medical Ltd.) was precordially inserted through a pocket created immediately below the xiphoid process, as described previously . During the preparation period, rectal temperature was maintained at 37.5 ± 0.5°C.…”
Section: Methodsmentioning
confidence: 99%
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“…Pralidoxime may also facilitate successful resuscitation by reducing the ischemic contracture, thus improving the hemodynamic efficacy of CPR. 2,3-Butanedione monoxime (BDM) has been found to reverse ischemic contracture and improve resuscitability in a pig model of cardiac arrest [10,11]. Both BDM and pralidoxime belong to the oxime family and have common mechanisms of action [12].…”
Section: Introductionmentioning
confidence: 99%