2,3‐Dimercaptopropanol, 2,3‐Dimercaptopropane‐1‐sulfonic Acid and <i>meso</i>‐2,3‐Dimercaptosuccinic Acid Acute Administration Diferentially Change Biochemical Parameters in Mice

Santos, Francielli Weber; Goncales, Carlos E.P.; Rocha, João Batista Teixeira da; ogueira, Cristina Wayne

doi:10.1111/j.1742-7843.2005.pto960409.x

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…34,36 Several studies have described a potential interaction between DMSA and zinc. 37,38 Further in vitro studies may be performed to study the intimate interactions between NDM-1, DMSA and zinc. We may study the hydrolysis of NDM-1 in the presence of increasing concentrations of DMSA followed by increasing concentration of zinc to see if the inhibition of hydrolysis of NDM-1 is reversible or irreversible.…”

Section: Discussionmentioning

confidence: 99%

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet

Lastours

Poirel

et al. 2020

Journal of Antimicrobial Chemotherapy

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Background Carbapenemase-producing Enterobacterales represent a major therapeutic challenge. MBLs, requiring zinc at their catalytic site, could be inhibited by meso-dimercaptosuccinic acid (DMSA), a heavy metal chelator already widely used for treating lead intoxication. Objectives To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in a severe murine peritonitis model. Methods Isogenic strains of wild-type E. coli CFT073 producing the MBLs NDM-1, VIM-2 and IMP-1, and the control serine carbapenemases OXA-48 and KPC-3 were constructed. MIC determinations and time–kill assays were performed for imipenem, meropenem and ertapenem alone or in combination with DMSA. Infected mice were treated intraperitoneally for 24 h with imipenem, DMSA or their combination. Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. Results DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains. In mice infected with the NDM-1-producing strain, the combination of imipenem and DMSA significantly reduced bacterial counts in peritoneal fluid (P = 0.0006) and spleen (P < 0.0001), as compared with imipenem alone, with no benefit against the KPC-3-producing and CFT073 strains. DMSA concentrations in plasma of mice were comparable to those obtained in humans with a standard oral dose. Conclusions DMSA restores the activity of carbapenems against MBL-producing strains, and its combination with carbapenems appears to be a promising strategy for the treatment of NDM-producing E. coli infections.

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Section: Discussionmentioning

confidence: 99%

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Cheminet

Lastours

Poirel

et al. 2020

Journal of Antimicrobial Chemotherapy

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A study of mercury(II)-catalysed substitution of cyanide in hexacyanoferrate(II) by 2-methylpyrazine: effects of inhibitor on the catalysed reaction

Bansal

2009

Transition Met Chem

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The kinetics and mechanism of the mercury(II)-catalysed ligand substitution reaction between potassium hexacyanoferrate(II) and 2-methylpyrazine (2-Mepz), in potassium hydrogen phthalate buffer of pH 3.50 ± 0.02 at 25.0 ± 0.1°C and constant ionic strength of 0.1 M, were studied spectrophotometrically by measuring the absorbance of the yellow-coloured product at 447 nm (k max ). The reaction was studied under pseudofirst-order conditions using excess of 2-Mepz. The reaction was found to obey first-order dependence in concentration of both [Fe(CN) 6 ] 4-and 2-Mepz. At higher concentrations of 2-Mepz, the effect of [2-Mepz] levels off. A complex behaviour is observed on varying [Hg 2? ]. The effect of pH on the reaction rate was also analysed. The effects of dielectric constant and water content of the reaction medium have been interpreted in terms of the formation of a polar activated complex and suggest an I d mechanism. The inhibitory effect of 2,3-dimercaptopropanol on the reaction was also studied and explained in terms of binding of this species to the catalyst.

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2,3‐Dimercaptopropanol, 2,3‐Dimercaptopropane‐1‐sulfonic Acid and meso‐2,3‐Dimercaptosuccinic Acid Acute Administration Diferentially Change Biochemical Parameters in Mice

Cited by 2 publications

References 24 publications

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

Dimercaptosuccinic acid in combination with carbapenems against isogenic strains of Escherichia coli producing or not producing a metallo-β-lactamase in vitro and in murine peritonitis

A study of mercury(II)-catalysed substitution of cyanide in hexacyanoferrate(II) by 2-methylpyrazine: effects of inhibitor on the catalysed reaction

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