2-[3-(Methyldiphenylsilyl)propyl]isoindoline-1,3-dione

Abstract

In the title compound, C24H23NO2Si, the dihedral angle between the planes of the phenyl rings attached to the Si atom is 80.78 (10)°. In the crystal, the mol­ecules form sheets lying perpendicular to [101] via C—H⋯O inter­actions. These sheets are stacked and linked in a three-dimensional framework by additional C—H⋯O inter­actions in the [10] direction.

2-[2-(Trimethylsilyl)ethyl]isoindoline-1,3-dione

“…The bond distances and angles of (I) are typical as confirmed by the Mogul structural check (Bruno et al, 2002), and agree well with those for the related compounds 2-(3-(methyldiphenylsilyl)propyl)isoindoline-1,3-dione (Guzei, Spencer, Zakai & Lynch, 2010) and 2-(((4-methoxyphenyl)dimethylsilyl)methyl)isoindoline-1,3-dione . Specifically, the average Si-C distances of 1.867 (3) Å for compound (I) are statistically similar to the 1.88 3 The pattern formed can be described in graph set notation as R 2 2 (10) (Grell et.…”

“…For literature related to drug design see: Bains & Tacke (2003); Bikzhanova et al (2007); Franz (2007); Franz et al (2007); ; Guzei,, Spencer, Zakai & Lynch (2010); ; Lee et al (1993Lee et al ( , 1996; Sen & Roach (1995); Showell & Mills (2003); Tacke & Zilch (1986); Tsuge et al (1985); Yoon et al (1991Yoon et al ( , 1992Yoon et al ( , 1997. For a description of the Cambridge Structural Database, see: Allen (2002).…”

2-{[(4-Methoxyphenyl)dimethylsilyl]methyl}isoindoline-1,3-dione

“…The bond distances and angles of (I) are typical as confirmed by the Mogul structural check (Bruno et al, 2004), and agree well with those for 2-(3-(methyldiphenylsilyl)propyl)isoindoline-1,3-dione (Guzei, Spencer, Zakai & Lynch, 2010) and 2-(2-(trimethylsilyl)ethyl)isoindoline-1,3-dione . Specifically, the average Si-C distances of 1.868 (19) Å for compound (I) are statistically similar to the 1.859 (6) Å average for six related compounds in the Cambridge Structural Database (Version 1.11, September 2009 release; Allen, 2002).…”

Bruker SMART X2S Benchtop System: A Means To Making X-ray Crystallography More Mainstream in the Undergraduate Laboratory

“…We conclude that the instrument hardware is robust and well suited for routine crystallographic characterization of both stable organic and organometallic compounds. Six articles − based on the data acquired have been published in the crystallographic journal Acta Crystallographica E , which rigorously checks crystal data and structure quality.…”

“…This system has been successfully tested at the American Crystallographic Association 2009 summer school and sold to at least three chemistry sites in the United States. The informal reviews were good and several articles containing structural results based on SMART X2S data have been published by others − and by us − .…”