2.3 THz radiation: Absence of genotoxicity/mutagenicity in Escherichia coli and Salmonella typhimurium

Sergeeva, Svetlana V.; Demidova, Elisaveta V.; Синицына, О. И.; Goryachkovskaya, T. N.; Bryanskaya, A. V.; Semenov, Artem I.; Meshcheryakova, I. A.; Dianov, Grigory L.; Popik, V. M.; Peltek, Sergey E.

doi:10.1016/j.mrgentox.2016.05.005

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…It can be assumed that in this case a membrane also functions as a screen which does not allow any impact of the external THz field on the process of differentiation. The third type of non-sensitive cells is bacterial cells [18]. We believe that in this case a membrane also protects a microorganism from the external THz field.…”

Section: Discussionmentioning

confidence: 97%

“…Currently, there is no consensus on this issue. Some studies have demonstrated that this effect does not occur [18][19][20][21][22][23][24][25], whereas in other works the effect was clearly displayed [10][11][12][26][27][28]. Particularly, experiments in papers [19,20,25,28] showed different results after exposure of THz radiation of approximately same frequency (0.10 -0.15 THz) and power density (0.04 -5 mW/cm 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of terahertz radiation influence on rat glial cells

Borovkova

Серебрякова

Федоров

et al. 2016

Biomed. Opt. Express

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We studied an influence of continuous terahertz (THz) radiation (0.12 - 0.18 THz, average power density of 3.2 mW/cm) on a rat glial cell line. A dose-dependent cytotoxic effect of THz radiation is demonstrated. After 1 minute of THz radiation exposure a relative number of apoptotic cells increased in 1.5 times, after 3 minutes it doubled. This result confirms the concept of biological hazard of intense THz radiation. Diagnostic applications of THz radiation can be restricted by the radiation power density and exposure time.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Investigation of terahertz radiation influence on rat glial cells

Borovkova

Серебрякова

Федоров

et al. 2016

Biomed. Opt. Express

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show abstract

“…In order to precisely measure the influence of CW THz radiation on different objects, including biological ones [15], it is crucial to have a stable average THz power over a long period of time (hours). However, this is quite a challenging task.…”

Section: Resultsmentioning

confidence: 99%

Electronic Modulation of THz Radiation at NovoFEL: Technical Aspects and Possible Applications

et al. 2019

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The Novosibirsk Free Electron Laser (NovoFEL) facility is able to produce high-power tunable terahertz (THz) laser radiation in quasi-continuous mode. The ability to control/shape this THz radiation is required in a number of user experiments. In this work we propose a modulation approach suitable for free electron lasers based on recuperation design. It allows for generating THz macropulses of a desirable length, down to several microseconds (limited by a quality factor of FEL optical resonator). Using this approach, macropulses in the time window from several microseconds to several hundred microseconds have been shown for three possible frequency ranges: mid-infrared (~1100 cm−1), far-infrared (~200 cm−1) and THz (~40 cm−1). In each case, the observed rise and decay of the macropulse have been measured and interpreted. The advantage of using short macropulses at the maximum peak power available has been demonstrated with the time-resolved Electron Paramagnetic Resonance (EPR) spectroscopy.

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“…In recent years, increasing research attention has been focused on the frequency range near 0.1 THz (0.031-5 mW/cm 2 ) [7][8][9][10][11][12][13], which studied genomic instability and damage, genotoxicity, morphological changes, enzyme activity, etc. In addition, a number of studies have focused on the frequency range near 2 THz (0.03 mW/cm 2 -1.4 W/cm 2 ) [14][15][16][17][18][19], which studied gene expression, DNA damages, genotoxicity, inflammatory responses and stress systems etc. Research that examines the biological effects of exposure to the 0.2-2.0 THz frequency range is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Verification of Non-thermal Effects of 0.3–0.6 THz-Waves on Human Cultured Cells

et al. 2019

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Recent progress has been made in the development of terahertz (THz) waves for practical applications. Few studies that have assessed the biological effects of THz waves have been reported, and the data currently available regarding the safety of THz waves is inadequate. In this study, the effect of THz wave exposure on two cultured cells was assessed using a widely tunable THz source with a 0.3–0.6 THz frequency range, which can be used and increased in one GHz increments. The THz waves applied to the cultured cells were weak enough such that any thermal effects could be disregarded. The influence of THz wave exposure on both the proliferative and metabolic activities of these cells was investigated, as well as the extent of the thermal stress placed on the cells. In this work, no measurable effect on the proliferative or metabolic activities of either cell type was observed following the exposure to THz waves. No differences in the quantity of cDNA related to heat shock protein 70 was detected in either the sham or exposure group. As such, no differences in cellular activity between cells exposed to THz waves and those not exposed were observed.

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2.3 THz radiation: Absence of genotoxicity/mutagenicity in Escherichia coli and Salmonella typhimurium

Cited by 17 publications

References 35 publications

Investigation of terahertz radiation influence on rat glial cells

Investigation of terahertz radiation influence on rat glial cells

Electronic Modulation of THz Radiation at NovoFEL: Technical Aspects and Possible Applications

Verification of Non-thermal Effects of 0.3–0.6 THz-Waves on Human Cultured Cells

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