2,4,5-Triphenyl-1-(prop-2-en-1-yl)-1<i>H</i>-imidazole

Akkurt, Mehmet; Mohamed, Shaaban K.; Marzouk, Adel A.; Abbasov, V. М.; Santoyo‐González, Francisco

doi:10.1107/s1600536813014104

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…13 C NMR of 8l–s showed five characteristic significant signals around 13.000, 21.000, 28.000, 29.000, and 44.000, which belong to the carbon atoms of pentyl moiety, and the peak of methylene disappeared in DEPT confirming that, in the other hand, the structure of the compounds 8a , 8b , 8d , 8e , 8i , 8l , 8n , 8r , and 8s were confirmed by X‐ray single crystal analysis (Fig. ) .…”

Section: Resultsmentioning

confidence: 63%

“…Also, compounds 8a–s were prepared by second method via alkylation of 2,4,5‐trisubstituted imidazoles with allyl bromide or pentyl bromide in DMSO/KOH system at 30–60°C. However, alkylation of imidazole method afforded better yields of the product under mild conditions in a shorter reaction time (Scheme ) .…”

Section: Resultsmentioning

confidence: 99%

“…The molecular structures of 8a , 8b , 8d , 8e , 8i , 8l , 8n , 8r , and 8s showing the atom numbering with ellipsoids drawn at the 50% probability level . [Color figure can be viewed at wileyonlinelibrary.com]…”

Section: Resultsmentioning

confidence: 99%

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New Method for Synthesis of Multi‐substituted Imidazoles

Marzouk

Mohamed

Aljohani

et al. 2018

Journal of Heterocyclic Chem

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in Wiley Online Library (wileyonlinelibrary.com).Here, we reported two methods for the synthesis of multi-substituted imidazoles, firstly via fourcomponent cyclocondensation reaction of benzil, aliphatic amines (allylamine or pentylamine), and aromatic aldehyde and ammonium acetate. Using an ionic liquid catalyst namely, diethyl ammonium hydrogen sulfate, and under solvent-free conditions. Secondly, via the alkylation of synthesized NH imidazoles with alkyl halide (allyl bromide and pentyl bromide) gave 8a-c in high yield (average 90%), the products can be purified by a non-chromatographic method, and these newly synthesized compounds have been characterized by spectral data: FTIR, IR, 1 H, 13 C nuclear magnetic resonance, the elemental analysis, and the X-ray structure.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 99%

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New Method for Synthesis of Multi‐substituted Imidazoles

Marzouk

Mohamed

Aljohani

et al. 2018

Journal of Heterocyclic Chem

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Morpholinium hydrogen sulfate (MHS) ionic liquid as an efficient catalyst for the synthesis of bio-active multi-substituted imidazoles (MSI) under solvent-free conditions

Marzouk

Abdelhamid

Mohamed

2016

Zeitschrift Für Naturforschung B

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Morpholinium hydrogen sulfate as an ionic liquid was employed as a catalyst for the synthesis of a biologically active series of multi-substituted imidazoles by a four-component reaction involving the combination of benzil with different aromatic aldehydes, ammonium acetate, and 1-amino-2-propanol under solvent-free conditions. The key advantages of this method are shorter reaction times, very high yield, and ease of processing. Furthermore, the resulting products can be purified by a non-chromatographic method and the ionic liquid catalyst is reusable. All of these novel compounds have been fully characterized from spectral data. The X-ray crystal structures of two representative molecules are also detailed.

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2,4,5-Triphenyl-1-(prop-2-en-1-yl)-1H-imidazole

Abstract: Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.003 Å; disorder in main residue; R factor = 0.062; wR factor = 0.183; data-to-parameter ratio = 10.6.

Cited by 2 publications

References 11 publications

New Method for Synthesis of Multi‐substituted Imidazoles

New Method for Synthesis of Multi‐substituted Imidazoles

Morpholinium hydrogen sulfate (MHS) ionic liquid as an efficient catalyst for the synthesis of bio-active multi-substituted imidazoles (MSI) under solvent-free conditions

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