2023
DOI: 10.1016/j.ejps.2023.106390
|View full text |Cite
|
Sign up to set email alerts
|

2′,4′-Dihydroxy-6′‑methoxy-3′,5′-dimethylchalcone and its amino acid-conjugated derivatives induce G0/G1 cell cycle arrest and apoptosis via BAX/BCL2 ratio upregulation and in silico insight in SiHa cell lines

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(3 citation statements)
references
References 54 publications
0
3
0
Order By: Relevance
“…It has been proposed that this ratio functions as a modulator, determining susceptibility to apoptosis, such that a decreased ratio is associated with tumor cells resistant to apoptosis (malignancy). In contrast, an increased ratio of Bax/Bcl is associated with cells sensitive to apoptosis [19,20].…”
Section: Discussionmentioning
confidence: 93%
“…It has been proposed that this ratio functions as a modulator, determining susceptibility to apoptosis, such that a decreased ratio is associated with tumor cells resistant to apoptosis (malignancy). In contrast, an increased ratio of Bax/Bcl is associated with cells sensitive to apoptosis [19,20].…”
Section: Discussionmentioning
confidence: 93%
“…42,43 In this study, we investigated the impact of dietary inclusion of CP on the degree of cell proliferation and apoptosis in the intestinal epithelial cells of largemouth bass by examining the expression levels of genes encoding Bcl-2 family proteins (the genes encoding the pro-apoptotic proteins Bax and Bad were bax and bad, respectively; and the genes encoding the anti-apoptotic proteins Bcl-xL and Bcl-2 were Bcl-xl and bcl-2, respectively), the expression level of the gene encoding the anti-apoptotic protein BAG (the bag gene), the expression level of the gene encoding caspase-3 (the casp3 gene), and changes in the bax/bcl2 ratio. 44,45 When the level of CP in feed ranged from 3% to 12%, the expression of the Bcl-xl and bag genes was significantly upregulated. The dietary inclusion of CP significantly decreased the expression levels of pro-apoptotic genes (the bax, bad, and casp3 genes) and the bax/bcl2 ratio, except when the level of CP in feed was 3%.…”
Section: Discussionmentioning
confidence: 99%
“…It is tightly regulated by multiple genes that are highly conserved across species, especially genes encoding proteins of the Bcl‐2 family or the caspase family 42,43 . In this study, we investigated the impact of dietary inclusion of CP on the degree of cell proliferation and apoptosis in the intestinal epithelial cells of largemouth bass by examining the expression levels of genes encoding Bcl‐2 family proteins (the genes encoding the pro‐apoptotic proteins Bax and Bad were bax and bad , respectively; and the genes encoding the anti‐apoptotic proteins Bcl‐xL and Bcl‐2 were Bcl‐xl and bcl‐2 , respectively), the expression level of the gene encoding the anti‐apoptotic protein BAG (the bag gene), the expression level of the gene encoding caspase‐3 (the casp3 gene), and changes in the bax / bcl2 ratio 44,45 . When the level of CP in feed ranged from 3% to 12%, the expression of the Bcl‐xl and bag genes was significantly upregulated.…”
Section: Discussionmentioning
confidence: 99%