2'-[(4-Fluorophenyl)carbonyl]-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indole-3,3'-pyrrolizin]-2(1H)-one

Abstract

A new spiro[indole-3,3'-pyrrolizine] derivative is regioselectively synthesized by the straightforward multicomponent reaction of 1-(4-fluorophenyl)-3-phenylprop-2-en-1-one, isatin and L-proline without any catalyst. The structure of the newly synthesized compound is characterized by IR, NMR, UV-visible and mass spectral data. The compound is also screened for its reducing power assay.

Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

“…The structure and regiochemistry of the products were confirmed by spectroscopic analysis. The structure of the newly prepared compounds was proposed by referring to the literature [22,23]. The 1 H NMR spectra of the compounds present only one set of signals and were comparable with that of the literature.…”

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

“…43 The possible mechanism of this reaction was investigated using a B3LYP/6-311G level of theory, and the results show that the regioselection depends on the energy barrier between the stacking state and the regioisomer. 44 …”

Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

“…Benzoheterodiazepine derivatives are designed from different reactants such as cinnamoylacetonitrile [64], hydrazone [65], flavone [66], chalcone [67], α-haloketones [68,69], ethyl acetoacetate [70], cinnamoyl cyanide [71], propargylic alcohols [72], or ketones [73][74][75]. The condensation of diamines (i.e., o-phenylenediamine, o-aminothiophenol, o-aminophenol) and chalcones [76,77] is common under different modes of reactions (i.e., stirring [78], grindstone [79], reflux [80,81], MW [82,83], and ultrasonic irradiations [84,85]) in the presence of catalysts (i.e., piperidine [86,87], NaOH [88,89], NaOAc [90], acetic acid [91,92], trifluoroacetic acid [93], InCl 3 [94], alumina [82], volcanic ash [95], Ti(OiPr) 4 [77], MgO-ZrO 2 [96], SmI 2 [78], SiO 2 [97], Al 2 O 3 [80], TiCl 4 /Sm [98], Bi(NO 3 ) 3 -Al 2 O 3 [99], La Y zeolite [100], HClO 4 -SiO 2 [101], Fe 3 O 4 [102], B(HSO 4 ) 3 …”