2-[5-(2-Methylphenyl)-3-(2-methylstyryl)-4,5-dihydro-1<i>H</i>-pyrazol-1-yl]-6-(thiophen-2-yl)-4-(trifluoromethyl)pyrimidine chloroform monosolvate

Flores, Alex F. C.; Flores, Darlene C.; Vicenti, Juliano Rosa de Menezes; Campos, Patrick T.

doi:10.1107/s160053681401321x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Synthesis Of Styrylpyrazoles1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gressler et al described the [3 + 2] cyclocondensation of 1,5-diarylpenta-1,4-dien-3-ones 31 with aminoguanidine hydrochloride 32 in ethanol, in the presence of triethylamine, as a method to prepare 5-aryl-1-carboxamidino-3-styryl-4,5-dihydro-1 H -pyrazoles 9 ( Scheme 5 ) [ 35 , 66 , 67 ].…”

Section: Synthesis Of Styrylpyrazolesmentioning

confidence: 99%

Styrylpyrazoles: Properties, Synthesis and Transformations

et al. 2020

View full text Add to dashboard Cite

The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time. This review article gives an overview of pyrazole derivatives that contain a styryl (2-arylvinyl) group linked in different positions of the pyrazole backbone. Although there are studies on the synthesis of styrylpyrazoles dating back to the 1970s and even earlier, this type of compound has rarely been studied. This timely review intends to summarize the properties, biological activity, methods of synthesis and transformation of styrylpyrazoles; thus, highlighting the interest and huge potential for application of this kind of compound.

show abstract

Section: Synthesis Of Styrylpyrazolesmentioning

confidence: 99%