2,7-dihydroxy-3-formyl-1-(3′-methyl-2′-butenyl)carbazole from Clausena lansium

Constituents from Clausena excavata

“…56, No. 6 clausenidin (10), 14,15) dentatin (11), 15,16) clausarin (12), 17) nordentatin (13), 18,19) xanthyletin (14), 20) xanthoxyletin (15), 20) murrayacoumarin C (16), 10) umbelliferone (17), 21) 3-formylcarbazole (18), 22) 2-methoxy-3-formylcarbazole (19), 23) 2-hydroxy-3-formyl-7-methoxycarbazole (20), 24) clausine C (21), 25) clausine E (22), 3) clausine K (23), 3) clausine L (24), 26) mukonal (25), 27) heptaphylline (26), 28) 2,7-dihydroxy-3-formyl-1-(3Ј-methyl-2Ј-butenyl)carbazole (27), 29) and heptazoline (28). 30) Compounds 19, 20, 22, 23, 26 and 27 were applied in a topoisomerase II inhibition activity test, which was measured by using ATP-dependent decatenation of kDNA.…”

A New Coumarin and Carbazole Alkaloid from Clausena vestita D. D. Tao

“…Clauszoline-K [17] (13 mg) was isolated from F 3f (190 mg). Carbalexin B [18] (10 mg), 3-formyl-2,7-dihydroxy-1-(3'-methylbut-2'-en-1'-yl)carbazole [19] (14 mg), and 2-hydroxy-3-methylcarbazole [6] (10 mg) were isolated from F 3g (147 mg). 3-Formyl-2,7-dihydroxy-1-(3'-methylbut-2'-en-1'-yl)carbazole [19] (9 mg) was also isolated from F 3h (60 mg).…”

New coumarins from Clausena lansium twigs

“…3 Previous chemical investigations of this plant have revealed a number of alkaloids and coumarins. 2,[4][5][6] As parts of our continuing study on chemical constituents and biological activity of Thai medicinal plants, we report herein the isolation and structure elucidation of two new coumarins (5 and 9) along with seven known coumarins (1-4, 6-8) from the twigs of C. lansium as well as the evaluation of cytotoxicity against KB, MCF7 and NCI-H187 cancer cell lines. In addition, the 1 H and 13 C NMR spectral data of 7 are also reported herein for the first time.…”