2-Acetylbenzofurans: Synthesis, Reactions and Applications

Metwally, M. A.; Abdel‐Wahab, Bakr F.; El‐Hiti, Gamal A.

doi:10.2174/138527210790226401

Cited by 24 publications

(10 citation statements)

References 56 publications

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“…3-Carbonylated benzofuran (3-CBF) derivatives represent an important class of members in the benzofuran family exhibiting unique biological and pharmacological activities . To date, many approaches have been explored for the construction of benzofuran scaffold with different functional patterns, − among which, however, those related to the synthesis of 3-CBFs have a lack of development. Representative methods include Pd-catalyzed cascade carbonylative annulation of o -hydroxyarylacetylenes in the presence of CO gas, − tandem Michael addition/cyclization of quinones with 1,3-dicarbonyl compounds or β-(dimethylamino)vinyl ketones, − CuI-catalyzed coupling of 1-bromo-2-iodobenzenes and β-keto esters, and BBr 3 -mediated domino ring cleavage/deprotection/annulation reaction of 2-alkylidenetetrahydrofurans .…”

mentioning

confidence: 99%

Gold(III)-Catalyzed Tandem Reaction ofO-Arylhydroxylamines with 1,3-Dicarbonyl Compounds: Highly Selective Synthesis of 3-Carbonylated Benzofuran Derivatives

Liu¹,

Qian²,

Lou³

et al. 2010

J. Org. Chem.

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confidence: 99%

Gold(III)-Catalyzed Tandem Reaction ofO-Arylhydroxylamines with 1,3-Dicarbonyl Compounds: Highly Selective Synthesis of 3-Carbonylated Benzofuran Derivatives

Liu¹,

Qian²,

Lou³

et al. 2010

J. Org. Chem.

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“…A wide pharmacology makes quinoline 4‐carboxylic acid as one of the most significant scales of quinoline derivatives . It was proved as a powerful analgesic, antimicrobial, and antifungal agents . Moreover, neocinchophen (II, Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Docking, ADME‐Tox Study of 2‐(2‐(2‐Chlorophenyl)quinoline‐4‐carbonyl)‐N‐substituted hydrazinecarbothioamide Derivatives and Their Biological Evaluation

Patel

Vekariya

Patel

et al. 2018

Journal of Heterocyclic Chem

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A series of 2‐(2‐(2‐chlorophenyl)quinoline‐4‐carbonyl)‐N‐substituted hydrazinecarbothioamide derivatives were synthesized by facile and efficient conventional method. The structures of the compounds were elucidated with the aid of an elemental analysis, IR, ESI‐MS, 1H‐NMR, and 13C‐NMR spectral data. The synthesized compounds were evaluated for their in vitro antibacterial, antifungal, antimalarial, and antituberculosis activity against standard drugs. The bacterial studies were determined against gram‐positive and negative bacteria. These compounds were found to a broad spectrum of activity against the screened bacteria, but poor activity was observed against Pseudomonas aeruginosa and Escherichia coli. Compounds 8d, 8f, 8i, 8l, and 8n showed the potent activity against Staphylococcus aureus. Compounds 8d, 8g, 8k, 8l, and 8q show the potent activity against antimalarial as compared with the standard drugs Chloroquine, Quinine and compounds 8h, 8n, and 8o shows mild activity against H37Rv strain. Molecular docking revealed that synthesized derivatives and target proteins were actively involved in a binding pattern and had a significant corelation with biological activity. We have also performed a molecular dynamics and ADME‐Tox parameters for the synthesized compounds.

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“…Benzofuran içeren yapılar kuvvetli biyolojik aktiviteye sahiptir [1] ve ilaç kimyasında etkin maddelerdir. Biyolojik olarak yararlı birçok bileşiğin üretiminde ve organik sentezinde geniş uygulama alanları bulmuştur [2]. Benzofuranların biyolojik aktiviteleri araştırıldığında antibakteriyel, antimikrobiyal, antifungal, antitümör ve antiinflamatuar (iltihap tedavisi) gibi birçok biyolojik aktiviteye sahip oldukları görülmüştür [3].…”

Section: Introductionunclassified

Methacrylate Polymers Having Pendant Chalcone Moieties: Monomer Reactivity Ratios, Thermal and Optical Properties

Barim¹,

Altun²,

Yayla³

2015

Polymer Korea

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A new methacrylate copolymer that includes chalcone as a side group, poly(4-methacryloyloxyphenyl-4'-methoxystyryl ketone-co-styrene) was synthesized by free radical copolymerization. FTIR and 1 H NMR spectroscopic techniques were used to characterize the homopolymers and copolymers. The copolymerizations were carried out to high conversions. Copolymer compositions were established by 1 H NMR spectra analysis. The monomer reactivity ratios for copolymer system were determined by the linearized Kelen Tüdös, and Extended Kelen Tüdös methods and a non-linear least squares method. The molecular weights and polydispersity index of copolymers were measured by using the gel permeation chromatography (GPC). The effect of copolymer compositions on their thermal behavior were studied by differential scanning calorimetry and thermogravimetric analysis methods. The optical properties of the resulting copolymer were also investigated.

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2-Acetylbenzofurans: Synthesis, Reactions and Applications

Cited by 24 publications

References 56 publications

Gold(III)-Catalyzed Tandem Reaction ofO-Arylhydroxylamines with 1,3-Dicarbonyl Compounds: Highly Selective Synthesis of 3-Carbonylated Benzofuran Derivatives

Gold(III)-Catalyzed Tandem Reaction ofO-Arylhydroxylamines with 1,3-Dicarbonyl Compounds: Highly Selective Synthesis of 3-Carbonylated Benzofuran Derivatives

Synthesis, Docking, ADME‐Tox Study of 2‐(2‐(2‐Chlorophenyl)quinoline‐4‐carbonyl)‐N‐substituted hydrazinecarbothioamide Derivatives and Their Biological Evaluation

Methacrylate Polymers Having Pendant Chalcone Moieties: Monomer Reactivity Ratios, Thermal and Optical Properties

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