2-Amino-1,3,4-Thiadiazole Derivatives as Potential Anti-Helicobacter Pylori Agents – At a Glance

Abstract

Helicobacter pylori is a major human pathogen that causes gastric and extra-gastric complications and infects around 50% of the global population. Gastric cancer is a serious consequence of H. pylori infection. About 89% of all gastric cancers can be attributed to this pathogen. Treatment is indicated for all infected patients, as a strategy to knock down the risk of gastric malignancy. Due to the high level of antimicrobial resistance, new medicines are needed to treat H. pylori infection. This paper presents 2-amino-1,3,4-thiadiazole derivatives which exhibited anti-H. pylori effect. Some of the reported compounds showed higher activity compared to standard drugs, making the 2-amino-1,3,4-thiadiazole core a possible pattern for future anti-H. pylori agents. Rezumat Helicobacter pylori este un agent patogen major care provoacă complicații gastrice și extra-gastrice și infectează aproximativ jumătate din populația lumii. Cancerul gastric este o consecință gravă a infecției cu H. pylori. Aproximativ 89% dintre toate tipurile de cancer gastric pot fi atribuite acestui agent patogen. Tratamentul este indicat tuturor pacienților infectați, ca strategie de reducere a riscului de cancer gastric. Datorită nivelului ridicat de rezistență antimicrobiană, sunt necesare noi medicamente pentru tratarea infecției cu H. pylori. Acest articol prezintă derivați de 2-amino-1,3,4-tiadiazol care au manifestat efect anti-H. pylori. Unii dintre compușii raportați au demonstrat activitate superioară medicamentelor standard, făcând din fragmentul de 2-amino-1,3,4-tiadiazol un posibil model structural pentru viitori compuşi cu activitate anti-H. pylori.

Actividad antimicrobiana de un sistema a base de un extracto vegetal y tres aceites esenciales

“…Valores menores son considerados como ausencia de actividad antimicrobiana. Esto es en base a otros estudios donde se evalúa actividad antimicrobiana de aceites esenciales (2,(17)(18)(19) .…”

A Qsar Study on Thiourea Derivatives - New Approaches in Drug Development

“…Thiourea derivatives are mostly under deep research for their applications in the medical field. Thiourea skeleton is frequently encountered in medicinal chemistry for its versatile applications as antibacterial [13,14,18,40], antifungal [7,25,43,45], antitumoral [1,10], antioxidant [6,17], anti-inflammatory [38], antiepileptic [5,41], anti-hypertensive [29,30].…”

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles

“…As such, there is still a demand for the expansion of ways to access new 1,2,3-triazole heterocyclic rings in rapid, efficient, and versatile ways. Triazole rings could serve as important intermediates for numerous important organic transformations [28][29][30]. Diverse applications of these five-membered N-heterocycles are the result of both their easy synthetic procedures and ring functionalization [9,31,32].…”