2-Anilino-5-benzoyl-4-phenyl-1,3-thiazole

Abstract

Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.003 Å; R factor = 0.047; wR factor = 0.116; data-to-parameter ratio = 18.0.Under basic conditions, methyl-N-phenylthiocarbomylphenylimidate and phenacyl bromide form the title compound, C 22 H 16 N 2 OS. X-ray diffraction shows that the crystal structure can be described as consisting of pseudo-dimers resulting from intermolecular N-HÁ Á ÁN hydrogen bonds, which are further stabilized by van der Waals interactions.

A solid solution of ethyl andd3-methyl 2-[(4-methylpyridin-2-yl)amino]-4-(pyridin-2-yl)thiazole-5-carboxylate

“…So far, few 5-substituted N-4-diaryl 2-aminothiazoles have been structurally characterized, viz. ANTZOB (Declercq et al, 1981), QAWDAT (Schantl & Lagoja, 1998), VAZNEQ (Shao et al, 2006), TIHKOL (Dridi & El Efrit, 2007), XIVCAJ and XIVCEN (Prevost et al, 2018). As far as we are able to ascertain, there are no published crystal structures of related 5-carboxylate N-4-diaryl 2-aminothiazoles, and just two for 5-carboxylate N,N-4-triaryl-2-aminothiazoles, NIBDEJ (Souldozi et al, 2013) and USAQIQ (Heydari et al, 2016), in which the formal C O group adopts an orientation antiperiplanar to the adjacent thiazole C-S bond, in contrast to 3 and 4.…”