2-Aryl-1-dialkylaminoalkylimidazo[1,2-a]benzimidazoles and their calcium ion antagonism

Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems

“…Yield 89-95%. Analogous yields were obtained at boiling the mixture of initial compounds in acetone for 8-10 h, in ethanol for 5-6 h, in butanol for 1.5-2 h. Hydrobromides of compounds IIIb, IIIc, IVbIVd were described in [21,22].…”

Synthesis and pharmacological activity of 2-methoxyphenyl-and 2-oxyphenyl-substituted 1-dialkylaminoalkylimidazo[1,2-a]-benzimidazoles

“…The biological properties of 1,2-disubstituted compounds are less thoroughly studied. However, our previous comparative study [10] of the calcium ion antagonist properties of the two isomers showed that 1-substituted compounds are much more active in this respect than the analogous derivatives of the 9H tautomer. In addition, water-soluble salts of 1-dialkyl-aminoalkyl-2-R-imida-zo-[1,2-a]benzimidazoles exhibited high local anesthetic properties [11].…”

“…In addition, water-soluble salts of 1-dialkyl-aminoalkyl-2-R-imida-zo-[1,2-a]benzimidazoles exhibited high local anesthetic properties [11]. In this context, we have used the approach developed previously [10,11], synthesized a series of isomeric 1-dialkylaminoalkylimidazo[1,2-a]benzimidazoles, and studied their pharmacological properties.…”

Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products

“…First, via the intramolecular thermal cyclization of 1-acylmethyl-2-(w-chloroalkylamino)benzimidazoles (VI, VII), which were obtained using the reaction of thionyl chloride with 1-acylmethyl-2-(w-ydroxyalkylamino)benzimidazoles (IV, V). The latter compounds were synthesized as proposed in [10,11]. Individual chloropropylamines VII could not be isolated because these intermediate compounds exhibited spontaneous cyclization with the formation of pyrimidobenzimidazole IX derivatives.…”