2-Aryl hydrazonopropanal pharmacophores as potent cytotoxic agents against human hepatocellular carcinoma cell line

Al‐Zaydi, Khadijah M.; Saleh, Tamer S.

doi:10.1007/s00044-019-02473-8

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2021

2024

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Cited by 4 publications

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“…Nintedanib (F) acts as triple angiokinase inhibitor [9] (Figure 1). In addition, arylhydrazono-1,3-diketone derivatives are useful synthons in the synthesis of a large number of biologically compounds [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Mixed isatin with 3-(2-(aryl)hydrazono)acetylacetone Mn(II), Co(II) and Ni(II) complexes: antibacterial evaluation and molecular properties prediction

Hassan¹

2021

Bull. Chem. Soc. Eth.

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The metal complexes {Ni (II), Co (II) and Mn (II)} of 3-(2-(aryl)hydrazono)acetylacetone with isatin were synthesized and screened for their in vitro antibacterial activity against four pathogenic microorganisms {two Gram‐positive and two Gram negative}. The results of antibacterial activities revealed that all the metal complexes 1-9 exhibited moderate activities. Also, Lipinski's rule of five (RO5) of the mixed ligand metal complexes were calculated by SwissADME website. KEY WORDS: Isatin, 3-(2-(Aryl)hydrazono)acetylacetone, Metal complexes, Antibacterial activities, Lipinski rules Bull. Chem. Soc. Ethiop. 2020, 34(3), 533-541. DOI: https://dx.doi.org/10.4314/bcse.v34i3.9

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Section: Introductionmentioning

confidence: 99%