2-Bromo-1-(1H-pyrazol-4-yl)ethanone: versatile precursors for novel mono-, bis- and poly{6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines}

Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules

“…Compound 35 was synthesized by the reaction of phenylhydrazine with ((dimethyl-amino) methylene)pentane-2,4-dione, obtained upon treatment of acetylacetone with dimethylformamide dimethylacetal (DMF/DMA), followed by bromination through treatment with Br 2 in AcOH. 52,76 In an attempt to construct novel tris(thiazole) linked to other heterocylic moieties aiming at achieving the concept of molecular hybridization, we studied the synthesis of novel 2,4,6-tris (…”

“…33,[46][47][48][49] Synthetic chemistry is a highly creative discipline due to its ability to create new methodologies to contribute to the discovery of new drugs, and to enable the synthesis of important molecules with novel properties and functions in reasonable yields with a direct impact on the welfare of the world. Motivated by these ndings and in conjunction with our ongoing research work on poly(heterocycles) as well as the new concept in drug design, [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] we report herein on the synthesis of novel hybrid molecules containing 1,3,5-triazine linked to different heterocyclic systems.…”

Synthesis of Novel Bis(thiazolylchromen‐2‐one) Derivatives Linked to Alkyl Spacer via Phenoxy Group

“…Motivated by these findings and in conjunction with our ongoing research work on bis‐heterocycles , we report herein on the synthesis of novel bis (thiazolylchromen‐2‐one) derivatives of expected biological application based on the presence of two pharmacophores with dual mode of action.…”

Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor

“…In this respect, many of these derivatives have been used as multiple fluorescent chemosensors, in an electron transport layer of an organic light emitting device, as biomarkers of hypoxic tumor cells, and as a receptor in fluorescent high-affinity ligand in dopamine D3. [11][12][13][14] In connection with the increasing interest of adoption of new synthetic methods in drug discovery, and in continuation to our recent applications of carbon-Michael [15][16][17][18] as well as aza-Michael 16 addition reactions as powerful tools for the synthesis of nitrogen containing heterocycles and their corresponding bisheterocycles, 15,17,[19][20][21][22][23][24][25][26] we report herein our investigation on the reactivity of 2-(3H-imidazo [4,5-b]pyrid-2yl)acetonitrile towards arylidenemalononitriles and bis-arylidenemalononitriles aiming at synthesizing novel mono-and bis-imidazo[1,2-a:5,4-b']dipyridine-6,8-dicarbonitriles. In addition, a theoretical density functional theory (DFT) study aims to determine the more stable regioisomer of the two possible expected isomeric products from the mentioned reactions as well as to investigate the efficacy of the target compounds as suitable candidate for NLO material.…”