2-Bromopalmitate inhibits malignant behaviors of HPSCC cells by hindering the membrane location of Ras protein
Chen Wang,
Zhao-Yang Cui,
Hai-Yan Chang
et al.
Abstract:Palmitoylation, which is mediated by protein acyltransferase (PAT) and performs important biological functions, is the only reversible lipid modification in organism. To study the effect of protein palmitoylation on hypopharyngeal squamous cell carcinoma (HPSCC), the expression levels of 23 PATs in tumor tissues of 8 HPSCC patients were determined, and high mRNA and protein levels of DHHC9 and DHHC15 were found. Subsequently, we investigated the effect of 2-bromopalmitate (2BP), a small-molecular inhibitor of … Show more
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