2-Chloroquinoline-3-carboxylic acid

Abstract

The crystal structure of the title compound, C10H6ClNO2, can be described by two types of crossed layers which are parallel to (110) and (10). The crystal packing is stabilized by inter­molecular C—H⋯O and O—H⋯N hydrogen bonds, resulting in the formation of a two-dimensional network and reinforcing the cohesion of the structure.

2-Bromoethyl 2-chloro-6-methylquinoline-3-carboxylate

“…Although extensive studies have been carried out in the past, selectivity clearly remains a common problem in radical bromination (Kikichi et al, 1998;Xu et al, 2003). In previous works, we have reported structure determination of some new quinoline derivatives (Benzerka et al, 2008;Ladraa et al, 2009;Ladraa et al, 2010). In this paper, we report the synthesis and structure determination of new compound, resulting from the radical bromination of 2-chloro-3-(1,3-dioxolan-2-yl)-6-methylquinoline, (I), under photocatalytic conditions.…”

“…For our previous work on the preparation of quinoline derivatives, see: Benzerka et al (2008); Ladraa et al (2009Ladraa et al ( , 2010. For radical bromination, see: Kikichi et al (1998); Xu et al (2003); Djerassi (1948); Newman & Lee (1972).…”

Ethyl 3-(2-chloro-5,8-dimethoxyquinolin-3-yl)-2-cyanooxirane-2-carboxylate

“…For applications of oxiranes, see: Hanson (1991); Kumar & Leelavathi (2007); Das et al (2007); Boukhris et al (1996); Ammadi et al, (1999). For our previous work on the preparation of quinoline derivatives, see: Bouraiou et al (2008); Benzerka et al (2008); Ladraa et al (2010). For weak hydrogen bonds, see: Desiraju & Steiner, (1999).…”

“…2-cyano-2-alkoxycarbonyloxiranes proved to be versatile reagents from which a large variety of compounds might be synthesized (Boukhris et al, 1996;Ammadi et al, 1999). In connection with our research program aimed at the synthesis and the biological evaluation of quinoline derivatives (Bouraiou et al, 2008;Benzerka et al, 2008;Ladraa et al, 2010), we report in this paper the synthesis and the structure determination by X-ray of a new quinoline compound where quinolyl moiety is linked to functionalized oxirane system.…”