2-D material enhanced ultrasensitive electrochemical sensing of Pro-BNP peptide towards the risk-assessment of human heart

Goswami, Partha Pratim; Rotake, Dinesh; Singh, Shiv Govind

doi:10.1016/j.snb.2022.131382

Cited by 16 publications

(13 citation statements)

References 51 publications

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“…The diffraction peaks, including (001) at ≈15.0° and other planes observed for pure SnS 2 and its composites, correspond to the 2H hexagonal phase of SnS 2 (JCPDF no. 01-1010). , The high intensity of the peak corresponding to the (001) plane indicates that SnS 2 nanosheets stack preferentially along the [001] direction . The diffraction peaks of the MWCNTs are not visible in the XRD pattern of composites, probably due to the relatively lower content and poor crystallinity of the MWCNTs.…”

Section: Resultsmentioning

confidence: 99%

“…The SnS 2 /MWCNT composite was synthesized using a one-step hydrothermal method . To initiate this process, 0.5 g of SDS was added to 65 mL of DI water and bath sonicated for 20 min to make sure it dissolved completely.…”

Section: Methodsmentioning

confidence: 99%

“…The likely reactions leading to the synthesis of SnS 2 are shown below. Tin ions after interaction with hydrogen sulfide produced during the first step give rise to the formation of SnS 2 normalH 2 normalN normalC normalS normalN normalH 2 + 2 normalH 2 normalO → normalC normalO 2 + 2 normalN normalH 3 + normalH 2 normalS normalS normaln 4 + + 2 normalH 2 normalS → normalS normaln normalS 2 + 4 normalH + In another independent synthesis, composites were synthesized using the abovementioned process but with the addition of MWCNTs along with SnS 2 precursors, as shown in Figure . Various quantities of MWCNTs were added, and the resulting SnS 2 /MWCNT samples were labeled as follows: MW1 (5 mg), MW2 (10 mg), MW3 (20 mg), and MW4 (30 mg), where the quantity in parentheses is the mass of MWCNTs added during synthesis.…”

Section: Methodsmentioning

confidence: 99%

“…The SnS 2 /MWCNT composite was synthesized using a one-step hydrothermal method. 57 To initiate this process, 0.5 g of SDS was added to 65 mL of DI water and bath sonicated for 20 min to make sure it dissolved completely. Then, 0.8 g of tin chloride pentahydrate and 0.5 g of thiourea were dissolved in the same solution using magnetic stirring for 20 min.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…01-1010). 41,57 The high intensity of the peak corresponding to the (001) plane indicates that SnS 2 nanosheets stack preferentially along the [001] direction. 41 The diffraction peaks of the MWCNTs are not visible in the XRD pattern of composites, probably due to the relatively lower content and poor crystallinity of the MWCNTs.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

et al. 2023

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High performance with lower power consumption is one among the essential features of a sensing device. Minute traces of hazardous gases such as NO2 are difficult to detect. Tin disulfide (SnS2) nanosheets have emerged as a promising NO2 sensor. However, their poor room-temperature conductivity gives rise to inferior sensitivity and sluggish recovery rates, thereby hindering their applications. To mitigate this problem, we present a low-cost ultrasensitive NO2 gas sensor with tin disulfide/multiwalled carbon nanotube (SnS2/MWCNT) nanocomposites, prepared using a single-step hydrothermal method, as sensing elements. Relative to pure SnS2, the conductivity of nanocomposites improved significantly. The sensor displayed a decrease in resistance when exposed to NO2, an oxidizing gas, and exhibited p-type conduction, also confirmed in separate Mott–Schottky measurements. At a temperature of 20 °C, the sensor device has a relative response of about ≈5% (3%) for 25 ppb (1 ppb) of NO2 with complete recovery in air (10 min) and excellent recovery rates with UV activation (0.3 min). A theoretical lower limit of detection (LOD) of 7 ppt implies greater sensitivity than all previously reported SnS2-based gas sensors, to the best of our knowledge. The improved sensing characteristics were attributed to the formation of nano p–n heterojunctions, which enhances the charge transport and gives rise to faster response. The composite sensor also demonstrated good NO2 selectivity against a variety of oxidizing and reducing gases, as well as excellent stability and long-term durability. This work will provide a fresh perspective on SnS2-based composite materials for practical gas sensors.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

et al. 2023

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Rapid ultrasensitive and specific BNP biosensor with LED readout

So,

Torres Quiñones,

Kim

et al. 2024

Biomed Microdevices

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Biosensing for diagnostics has risen rapidly in popularity over the past decades. With the discovery of new nanomaterials and morphologies, sensitivity is being constantly improved enough for reliable detection of trace biomarkers in human samples, like serum or sweat. This precision has enabled detailed research on the e cacy of biosensors. However, current biosensors suffer from reduced speed of operation. To make better use of this sensitivity, the development of a conductometric biosensor with insitu use of an LED display can provide rapid determination of sample results, steadily pushing biosensors toward more clinical, point-of-care (POC) applications. In this research, a simple LED (laser emitting diode) was used for facile optical determination and visual output of an ultrasensitive bio-signal ampli cation circuit was made to interface with a b-type natriuretic peptide (BNP) biosensor. Tuning circuit gain enables an elegant method for adjustable separation of concentrations into 3 discrete categories: sub-threshold, analog, and saturation regions. These regions corresponded to 0 < [C] < 500 pg/mL (LED off), 500 < [C] < 1000 pg/mL (LED varying intensity), and 1000 pg/mL < [C] (LED full intensity). System e cacy was tested using human blood serum samples from University of Pittsburgh Medical Center patients, which were able to be accurately detected and sorted for rapid lo-. determination without need for complex digital elements. Additional speci city testing suggests insigni cant impact of non-target biomarkers.

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Advanced nanomaterial-based biosensors for clinical diagnosis, environmental protection and industrial fermentation

Hasan,

Sakib,

Sabroj

et al. 2024

Comprehensive Materials Processing

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2-D material enhanced ultrasensitive electrochemical sensing of Pro-BNP peptide towards the risk-assessment of human heart

Cited by 16 publications

References 51 publications

Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

Rapid ultrasensitive and specific BNP biosensor with LED readout

Advanced nanomaterial-based biosensors for clinical diagnosis, environmental protection and industrial fermentation

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2-D material enhanced ultrasensitive electrochemical sensing of Pro-BNP peptide towards the risk-assessment of human heart

Cited by 16 publications

References 51 publications

Ultrasensitive Room-Temperature NO2 Detection Using SnS2/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

Ultrasensitive Room-Temperature NO2 Detection Using SnS2/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

Rapid ultrasensitive and specific BNP biosensor with LED readout

Advanced nanomaterial-based biosensors for clinical diagnosis, environmental protection and industrial fermentation

Contact Info

Product

Resources

About

Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation

Ultrasensitive Room-Temperature NO₂ Detection Using SnS₂/MWCNT Composites and Accelerated Recovery Kinetics by UV Activation