2-Ethyl-6-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Abstract

In the title compound, C14H13N3O2S, the imidazothia­diazole ring system and the methoxy­phenyl ring are not coplanar, having an angle of 31.60 (7)° between their mean planes. In the crystal structure, inter­molecular C—H⋯O hydrogen‐bond inter­actions link the mol­ecules into dimers and π–π stacking inter­actions reinforce the crystal cohesion.

Synthesis and antiproliferative activity of imidazo[2,1- b ][1,3,4]thiadiazole derivatives

“…The 2-aralkyl/alkyl/-6-aryl-imidazo[2,1-b] [1,3,4]thiadiazole derivatives 5-12, reported in Scheme 1, were prepared by reaction of 2-amino-5-substituted-1,3,4-thiadiazoles 1-3, with the appropriate phenacyl bromide (4). The compounds 5-9 were previously reported in the literature 18,19 and compound 12 reported in literature 20 without spectral data. For the compound 11, although commercial, we set up a procedure for its synthesis.…”