2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience

Komori, Tsuyoshi; Narabayashi, Isamu; Matsumura, Kaname; Matsuki, Mitsuru; Akagi, Hiroyuki; Ogura, Yasuharu; Aga, Fumitoshi; Adachi, I

doi:10.1007/s12149-007-0010-6

Cited by 104 publications

(71 citation statements)

References 17 publications

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“…The role of DWIBS in the detection of extra-bone primary tumors has been demonstrated in a few experiences, with heterogeneous populations and low numbers of patients [15,16]. DWIBS imaging provides image with high contrast-to-noise ratio (CNR), leading to easy identification of small lesions during visual analysis and shortening reading time required to review the huge number of images provided by conventional WB-MRI.…”

Section: Discussionmentioning

confidence: 99%

Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

Manenti

Cicciò

Squillaci

et al. 2012

European Journal of Radiology

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Keywords:Whole-body magnetic resonance imaging (WB-MRI) Diffusion weighted imaging (DWI) Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) Positron emission tomography-computed tomography (PET-CT) Cancer staging a b s t r a c t Objectives: To assess the diagnostic performance of whole-body magnetic resonance imaging (WB-MRI) by diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in malignant tumor detection and the potential diagnostic advantages in generating fused DWIBS/3D-contrast enhanced T1w (3D-CE-T1w) images. Methods: 45 cancer patients underwent 18F-FDG PET-CT and WB-MRI for staging purpose. Fused DWIBS/3D-CE T1w images were generated off-line. 3D-CE-T1w, DWIBS images alone and fused with 3D-CE T1w were compared by two readers groups for detection of primary diseases and local/distant metastases. Diagnostic performance between the three WB-MRI data sets was assessed using receiver operating characteristic (ROC) curve analysis. Imaging exams and histopathological results were used as standard of references. Results: Areas under the ROC curves of DWIBS vs. 3D-CE-T1w vs. both sequences in fused fashion were 0.97, 0.978, and 1.00, respectively. The diagnostic performance in tumor detection of fused DWIBS/3D-CE-T1w images were statistically superior to DWIBS (p < 0.001) and 3D-CE-T1w (p ≤ 0.002); while the difference between DWIBS and 3D-CE-T1w did not show statistical significance difference. Detection rates of malignancy did not differ between WB-MRI with DWIBS and 18F-FDG PET-CT. Conclusion: WB-MRI with DWIBS is to be considered as alternative tool to conventional whole-body methods for tumor staging and during follow-up in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

Manenti

Cicciò

Squillaci

et al. 2012

European Journal of Radiology

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“…Diffusion of water molecules in malignant tumors is usually restricted compared to that in normal tissue, resulting in a decreased apparent diffusion coefficient (ADC) value (Szafer et al, 1995;Takahara et al, 2004). Some recent studies comparing DWI with FDG-PET have shown that DWI at 1.5 T is comparable with FDG-PET for detecting malignant lesions (Komori et al, 2007;Nomori et al, 2008;Mori et al, 2008), and an meta-analysis has shown that DWI can be used to differentiate malignant from benign pulmonary lesions . It is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary nodules and masses.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Many investigators have recently reported that body diffusion-weighted magnetic resonance imaging (DWI) may be useful not only for detecting malignant tumors and their metastatic spreads with high conspicuity (7)(8)(9)(10)(11), but also for tumor characterization (12)(13)(14)(15)(16)(17)(18)(19). Usually malignant tumors, including metastatic lesions, show bright signal on DWIs, and the apparent diffusion coefficient (ADC) values of malignant tumors are lower than the corresponding value of benign tumors.…”

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confidence: 99%

Diagnostic utility of diffusion‐weighted MR imaging and apparent diffusion coefficient value for the diagnosis of adrenal tumors

Tsushima

Takahashi-Taketomi

Endo

2008

Magnetic Resonance Imaging

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Purpose:To determine the utility of diffusion-weighted MR imaging (DWI) for the diagnosis of adrenal tumors. Ϫ3 ; 0.51-1.23; p ϭ 0.14). Pheochromocytomas showed the higher mean ADC value (1.59 Ϯ 0.34*10 Ϫ3 ; 1.04 -1.96) compared with those of adenomas or metastatic tumors (P Ͻ 0.05 and P Ͻ 0.005, respectively). The mean SII of adenomas (62.1 Ϯ 17.9%; 14.5-88.4) was significantly higher than those of pheochromocytomas (4.0 Ϯ 10.0%; Ϫ19.6 -3.3; P Ͻ 0.005) or metastatic tumors (Ϫ1.5 Ϯ 11.7%; Ϫ18.3-8.2; P Ͻ 0.01). There was no correlation between ADC values and SII. Materials and Methods Conclusion:Although pheochromocytomas showed higher ADC values, we did not find that ADC value had diagnostic utility for differentiating adenomas and metastatic tumors.

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2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience

Abstract: DWIBS can be used for the detection of malignant tumors or benign tumors; however, it may be difficult to differentiate between benign and malignant lesions by ADC.

Cited by 104 publications

References 17 publications

Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Diagnostic utility of diffusion‐weighted MR imaging and apparent diffusion coefficient value for the diagnosis of adrenal tumors

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