2-Hydroxy-1-((2-(pyridin-2-yl)hydrazono)methyl)tryptanthrin as a Fluorescent Chemosensor for Metal Ions

Abstract

2-Hydroxy-1-((2-(pyridin-2-yl)hydrazono)methyl)tryptanthrin (T2OH1CH=N-NH-Pyri) was synthesized and applied as a fluorescent chemosensor for metal ions. We investigated the metalion recognition of T2OH1CH=N-NH-Pyri in separate Li

Tryptanthrin from indigo: Synthesis, excited state deactivation routes and efficient singlet oxygen sensitization

“…Successful fluorescent imaging in cells and tissues requires the application of dyes which absorb and emit in the "optical window" (concerning the near-infrared (NIR) region of the electromagnetic spectrum -650-900 nm). This selectivity is required to avoid the interference of endogenous substances during the fluorescent imaging process, as well as to improve tissue penetration levels [30][31][32][33][34][35].…”

Recent advances of tryptanthrin and its derivatives as potential anticancer agents

“…49,[51][52][53]56,60 The ketone group in the sixth position of the indolo[2,1-b]quinazoline-6,12dione core can be also replaced with different functional groups to produce other spiro-tryptanthrin, 65,66 tryptanthrin aminothiazole, 67 tryptanthrin-6-oxime 52 and 8-halogensubstituted-6-hydrazono tryptanthrin 68 derivatives with various in vitro antitumor activities. In addition, tryptanthrin derivatives can also emit near-infrared fluorescence suitably applied as highly sensitive and selective fluorescent probes for biological metal ions, 69,70 indicating environmental significance. Kaur et al in 2017 reviewed the syntheses and biological activities of tryptanthrin and its related derivatives in last two decades, 12b but there has been no consideration of tryptanthrin metal complexes with anticancer activities in this review.…”

Solid-State Fluorescence of Tryptanthrin Analogs

“…We previously explored the photophysical properties of tryptanthrin derivatives used as novel fluorescent dyes [1][2][3][4][5][6][7][8]. Tryptanthrin (T, Fig.…”